Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene

Anita Bonne; Lilian Vreede; Roland P Kuiper; Danielle Bodmer; Corine Jansen; Marc Eleveld; Femke van Erp; Ger Arkesteijn; Nicoline Hoogerbrugge; Conny van Ravenswaaij; Eric F P M Schoenmakers; Ad Geurts van Kessel

doi:10.1016/j.cancergencyto.2007.07.005

Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene

Anita Bonne
, Lilian Vreede
, Roland P Kuiper
, Danielle Bodmer
, Corine Jansen
, Marc Eleveld
, Femke van Erp
, Ger Arkesteijn
, Nicoline Hoogerbrugge
, Conny van Ravenswaaij
, Eric F P M Schoenmakers
, Ad Geurts van Kessel

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Our group and others had previously developed a high throughput procedure to map translocation breakpoints using chromosome flow sorting in conjunction with microarray-based comparative genomic hybridization (arrayCGH). Here we applied both conventional positional cloning and integrated arrayCGH procedures to the mapping of constitutional chromosome anomalies in four patients with renal cell cancer (RCC), three with a chromosome 3 translocation, and one with an insertion involving chromosome 3. In one of these patients, who was carrying a t(3;4)(p13;p15), the KCNIP4 gene was found to be disrupted. KCNIP4 belongs to a family of potassium channel-interacting proteins and is highly expressed in normal kidney cells. In addition, KCNIP4 splice variants have specifically been encountered in RCC.

Original language	English
Pages (from-to)	11-8
Number of pages	8
Journal	Cancer genetics and cytogenetics
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2007.07.005
Publication status	Published - Nov 2007
Externally published	Yes

Keywords

Carcinoma, Renal Cell/genetics
Cell Line, Tumor
Chromosome Breakage
Chromosome Mapping
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 4
Cloning, Molecular
Humans
In Situ Hybridization, Fluorescence
Kidney Neoplasms/genetics
Kv Channel-Interacting Proteins/genetics
Loss of Heterozygosity
Mutagenesis, Insertional
Translocation, Genetic

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10.1016/j.cancergencyto.2007.07.005

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Bonne, A., Vreede, L., Kuiper, R. P., Bodmer, D., Jansen, C., Eleveld, M., van Erp, F., Arkesteijn, G., Hoogerbrugge, N., van Ravenswaaij, C., Schoenmakers, E. F. P. M., & Geurts van Kessel, A. (2007). Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene. Cancer genetics and cytogenetics, 179(1), 11-8. https://doi.org/10.1016/j.cancergencyto.2007.07.005

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title = "Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene",

abstract = "Our group and others had previously developed a high throughput procedure to map translocation breakpoints using chromosome flow sorting in conjunction with microarray-based comparative genomic hybridization (arrayCGH). Here we applied both conventional positional cloning and integrated arrayCGH procedures to the mapping of constitutional chromosome anomalies in four patients with renal cell cancer (RCC), three with a chromosome 3 translocation, and one with an insertion involving chromosome 3. In one of these patients, who was carrying a t(3;4)(p13;p15), the KCNIP4 gene was found to be disrupted. KCNIP4 belongs to a family of potassium channel-interacting proteins and is highly expressed in normal kidney cells. In addition, KCNIP4 splice variants have specifically been encountered in RCC.",

keywords = "Carcinoma, Renal Cell/genetics, Cell Line, Tumor, Chromosome Breakage, Chromosome Mapping, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 4, Cloning, Molecular, Humans, In Situ Hybridization, Fluorescence, Kidney Neoplasms/genetics, Kv Channel-Interacting Proteins/genetics, Loss of Heterozygosity, Mutagenesis, Insertional, Translocation, Genetic",

author = "Anita Bonne and Lilian Vreede and Kuiper, \{Roland P\} and Danielle Bodmer and Corine Jansen and Marc Eleveld and \{van Erp\}, Femke and Ger Arkesteijn and Nicoline Hoogerbrugge and \{van Ravenswaaij\}, Conny and Schoenmakers, \{Eric F P M\} and \{Geurts van Kessel\}, Ad",

year = "2007",

month = nov,

doi = "10.1016/j.cancergencyto.2007.07.005",

language = "English",

volume = "179",

pages = "11--8",

journal = "Cancer genetics and cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

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}

Bonne, A, Vreede, L, Kuiper, RP, Bodmer, D, Jansen, C, Eleveld, M, van Erp, F, Arkesteijn, G, Hoogerbrugge, N, van Ravenswaaij, C, Schoenmakers, EFPM & Geurts van Kessel, A 2007, 'Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene', Cancer genetics and cytogenetics, vol. 179, no. 1, pp. 11-8. https://doi.org/10.1016/j.cancergencyto.2007.07.005

TY - JOUR

T1 - Mapping of constitutional translocation breakpoints in renal cell cancer patients

T2 - identification of KCNIP4 as a candidate gene

AU - Bonne, Anita

AU - Vreede, Lilian

AU - Kuiper, Roland P

AU - Bodmer, Danielle

AU - Jansen, Corine

AU - Eleveld, Marc

AU - van Erp, Femke

AU - Arkesteijn, Ger

AU - Hoogerbrugge, Nicoline

AU - van Ravenswaaij, Conny

AU - Schoenmakers, Eric F P M

AU - Geurts van Kessel, Ad

PY - 2007/11

Y1 - 2007/11

N2 - Our group and others had previously developed a high throughput procedure to map translocation breakpoints using chromosome flow sorting in conjunction with microarray-based comparative genomic hybridization (arrayCGH). Here we applied both conventional positional cloning and integrated arrayCGH procedures to the mapping of constitutional chromosome anomalies in four patients with renal cell cancer (RCC), three with a chromosome 3 translocation, and one with an insertion involving chromosome 3. In one of these patients, who was carrying a t(3;4)(p13;p15), the KCNIP4 gene was found to be disrupted. KCNIP4 belongs to a family of potassium channel-interacting proteins and is highly expressed in normal kidney cells. In addition, KCNIP4 splice variants have specifically been encountered in RCC.

AB - Our group and others had previously developed a high throughput procedure to map translocation breakpoints using chromosome flow sorting in conjunction with microarray-based comparative genomic hybridization (arrayCGH). Here we applied both conventional positional cloning and integrated arrayCGH procedures to the mapping of constitutional chromosome anomalies in four patients with renal cell cancer (RCC), three with a chromosome 3 translocation, and one with an insertion involving chromosome 3. In one of these patients, who was carrying a t(3;4)(p13;p15), the KCNIP4 gene was found to be disrupted. KCNIP4 belongs to a family of potassium channel-interacting proteins and is highly expressed in normal kidney cells. In addition, KCNIP4 splice variants have specifically been encountered in RCC.

KW - Carcinoma, Renal Cell/genetics

KW - Cell Line, Tumor

KW - Chromosome Breakage

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 3

KW - Chromosomes, Human, Pair 4

KW - Cloning, Molecular

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Kidney Neoplasms/genetics

KW - Kv Channel-Interacting Proteins/genetics

KW - Loss of Heterozygosity

KW - Mutagenesis, Insertional

KW - Translocation, Genetic

U2 - 10.1016/j.cancergencyto.2007.07.005

DO - 10.1016/j.cancergencyto.2007.07.005

M3 - Article

C2 - 17981209

SN - 0165-4608

VL - 179

SP - 11

EP - 18

JO - Cancer genetics and cytogenetics

JF - Cancer genetics and cytogenetics

IS - 1

ER -

Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene

Abstract

Keywords

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