MARK-AGE biomarkers of ageing

Alexander Bürkle; María Moreno-Villanueva; Jürgen Bernhard; María Blasco; Gerben Zondag; Jan H.J. Hoeijmakers; Olivier Toussaint; Beatrix Grubeck-Loebenstein; Eugenio Mocchegiani; Sebastiano Collino; Efstathios S. Gonos; Ewa Sikora; Daniela Gradinaru; Martijn Dollé; Michel Salmon; Peter Kristensen; Helen R. Griffiths; Claude Libert; Tilman Grune; Nicolle Breusing; Andreas Simm; Claudio Franceschi; Miriam Capri; Duncan Talbot; Paola Caiafa; Bertrand Friguet; P. Eline Slagboom; Antti Hervonen; Mikko Hurme; Richard Aspinall

doi:10.1016/j.mad.2015.03.006

MARK-AGE biomarkers of ageing

Alexander Bürkle
, María Moreno-Villanueva
, Jürgen Bernhard
, María Blasco
, Gerben Zondag
, Jan H.J. Hoeijmakers
, Olivier Toussaint
, Beatrix Grubeck-Loebenstein
, Eugenio Mocchegiani
, Sebastiano Collino
, Efstathios S. Gonos
, Ewa Sikora
, Daniela Gradinaru
, Martijn Dollé
, Michel Salmon
, Peter Kristensen
, Helen R. Griffiths
, Claude Libert
, Tilman Grune
, Nicolle Breusing

Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Richard Aspinall

Research output: Contribution to journal › Article › peer-review

194 Citations (Scopus)

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Original language	English
Pages (from-to)	2-12
Number of pages	11
Journal	Mechanisms of Ageing and Development
Volume	151
DOIs	https://doi.org/10.1016/j.mad.2015.03.006
Publication status	Published - 1 Nov 2015
Externally published	Yes

Keywords

Ageing biomarkers
Human studies
MARK-AGE

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10.1016/j.mad.2015.03.006

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Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., ... Aspinall, R. (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151, 2-12. https://doi.org/10.1016/j.mad.2015.03.006

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title = "MARK-AGE biomarkers of ageing",

abstract = "Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.",

keywords = "Ageing biomarkers, Human studies, MARK-AGE",

author = "Alexander B{\"u}rkle and Mar{\'i}a Moreno-Villanueva and J{\"u}rgen Bernhard and Mar{\'i}a Blasco and Gerben Zondag and Hoeijmakers, \{Jan H.J.\} and Olivier Toussaint and Beatrix Grubeck-Loebenstein and Eugenio Mocchegiani and Sebastiano Collino and Gonos, \{Efstathios S.\} and Ewa Sikora and Daniela Gradinaru and Martijn Doll{\'e} and Michel Salmon and Peter Kristensen and Griffiths, \{Helen R.\} and Claude Libert and Tilman Grune and Nicolle Breusing and Andreas Simm and Claudio Franceschi and Miriam Capri and Duncan Talbot and Paola Caiafa and Bertrand Friguet and Slagboom, \{P. Eline\} and Antti Hervonen and Mikko Hurme and Richard Aspinall",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = nov,

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doi = "10.1016/j.mad.2015.03.006",

language = "English",

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Bürkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, JHJ, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dollé, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, Breusing, N, Simm, A, Franceschi, C, Capri, M, Talbot, D, Caiafa, P, Friguet, B, Slagboom, PE, Hervonen, A, Hurme, M & Aspinall, R 2015, 'MARK-AGE biomarkers of ageing', Mechanisms of Ageing and Development, vol. 151, pp. 2-12. https://doi.org/10.1016/j.mad.2015.03.006

TY - JOUR

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AU - Bürkle, Alexander

AU - Moreno-Villanueva, María

AU - Bernhard, Jürgen

AU - Blasco, María

AU - Zondag, Gerben

AU - Hoeijmakers, Jan H.J.

AU - Toussaint, Olivier

AU - Grubeck-Loebenstein, Beatrix

AU - Mocchegiani, Eugenio

AU - Collino, Sebastiano

AU - Gonos, Efstathios S.

AU - Sikora, Ewa

AU - Gradinaru, Daniela

AU - Dollé, Martijn

AU - Salmon, Michel

AU - Kristensen, Peter

AU - Griffiths, Helen R.

AU - Libert, Claude

AU - Grune, Tilman

AU - Breusing, Nicolle

AU - Simm, Andreas

AU - Franceschi, Claudio

AU - Capri, Miriam

AU - Talbot, Duncan

AU - Caiafa, Paola

AU - Friguet, Bertrand

AU - Slagboom, P. Eline

AU - Hervonen, Antti

AU - Hurme, Mikko

AU - Aspinall, Richard

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

AB - Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

KW - Ageing biomarkers

KW - Human studies

KW - MARK-AGE

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DO - 10.1016/j.mad.2015.03.006

M3 - Article

C2 - 25818235

AN - SCOPUS:84941698753

SN - 0047-6374

VL - 151

SP - 2

EP - 12

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

ER -

MARK-AGE biomarkers of ageing

Abstract

Keywords

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