Abstract
About 20% of all primary melanomas will spread. The likelihood of metastatic behavior correlates with prognostic factors such as tumor thickness, mitotic index, presence of ulceration, lymphocyte infiltration, age, gender, and anatomic site. Immunotherapies are developed for melanoma patients in stage IV who have distant metastases and in stage II to III patients in the adjuvant micrometastatic setting, where only a fraction of patients have widespread (microscopic) disease.
Original language | English |
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Pages (from-to) | 547-564 |
Number of pages | 18 |
Journal | Hematology/Oncology Clinics of North America |
Volume | 23 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 2009 |
Externally published | Yes |
Keywords
- Antibodies
- Cytokines
- Immunotherapy
- Melanoma
- Review
- Vaccines