Menadione inhibits MIBG uptake in two neuroendocrine cell lines

J. Cornelissen; G. A.M. Tytgat; M. Van Den Brug; A. B.P. Van Kuilenburg; P. A. Voûte; A. H. Van Gennip

doi:10.1023/A:1005718421774

Menadione inhibits MIBG uptake in two neuroendocrine cell lines

J. Cornelissen
, G. A.M. Tytgat
, M. Van Den Brug
, A. B.P. Van Kuilenburg
, P. A. Voûte
, A. H. Van Gennip

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In this paper we report on our studies of the effect of menadione on the uptake of MIBG in the neuroendocrine cell lines PC12 and SIC-N-SH. Menadione inhibits the uptake of MIBG in both cell lines in a dose-dependent manner. Inhibition of MIBG uptake is most pronounced in the PC12 cell line. Comparison of the inhibitory action of menadione on the uptake and retention of MIBG with that of imipramine and reserpine suggests that menadione inhibits uptake 1 mediated uptake as well as granular storage.

Original language	English
Pages (from-to)	147-151
Number of pages	5
Journal	Journal of Neuro-Oncology
Volume	31
Issue number	1-2
DOIs	https://doi.org/10.1023/A:1005718421774
Publication status	Published - 1997
Externally published	Yes

Keywords

Menadione
Meta-iodobenzylguanidine
Neuroblastoma
Oxidative stress
Uptake

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10.1023/A:1005718421774

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@article{efc1b2a7101042dba94e0d1e961192a7,

title = "Menadione inhibits MIBG uptake in two neuroendocrine cell lines",

abstract = "In this paper we report on our studies of the effect of menadione on the uptake of MIBG in the neuroendocrine cell lines PC12 and SIC-N-SH. Menadione inhibits the uptake of MIBG in both cell lines in a dose-dependent manner. Inhibition of MIBG uptake is most pronounced in the PC12 cell line. Comparison of the inhibitory action of menadione on the uptake and retention of MIBG with that of imipramine and reserpine suggests that menadione inhibits uptake 1 mediated uptake as well as granular storage.",

keywords = "Menadione, Meta-iodobenzylguanidine, Neuroblastoma, Oxidative stress, Uptake",

author = "J. Cornelissen and Tytgat, \{G. A.M.\} and \{Van Den Brug\}, M. and \{Van Kuilenburg\}, \{A. B.P.\} and Vo{\^u}te, \{P. A.\} and \{Van Gennip\}, \{A. H.\}",

note = "Funding Information: Paul Jonkergouw (Department of Safety, Health and Welfare, Nederlands Kanker Instituut) is thanked for preparing the [125I] MIBG. We would like to thank SJ and J Cook for critically reading of the manuscript. This study was supported by grant no. 92–03 from the {\textquoteleft}Stichting Kindergeneeskundig Kankeronderzoek{\textquoteright} (Foundation for Pediatric Cancer Research).",

year = "1997",

doi = "10.1023/A:1005718421774",

language = "English",

volume = "31",

pages = "147--151",

journal = "Journal of Neuro-Oncology",

issn = "0167-594X",

publisher = "Springer",

number = "1-2",

}

TY - JOUR

T1 - Menadione inhibits MIBG uptake in two neuroendocrine cell lines

AU - Cornelissen, J.

AU - Tytgat, G. A.M.

AU - Van Den Brug, M.

AU - Van Kuilenburg, A. B.P.

AU - Voûte, P. A.

AU - Van Gennip, A. H.

N1 - Funding Information: Paul Jonkergouw (Department of Safety, Health and Welfare, Nederlands Kanker Instituut) is thanked for preparing the [125I] MIBG. We would like to thank SJ and J Cook for critically reading of the manuscript. This study was supported by grant no. 92–03 from the ‘Stichting Kindergeneeskundig Kankeronderzoek’ (Foundation for Pediatric Cancer Research).

PY - 1997

Y1 - 1997

N2 - In this paper we report on our studies of the effect of menadione on the uptake of MIBG in the neuroendocrine cell lines PC12 and SIC-N-SH. Menadione inhibits the uptake of MIBG in both cell lines in a dose-dependent manner. Inhibition of MIBG uptake is most pronounced in the PC12 cell line. Comparison of the inhibitory action of menadione on the uptake and retention of MIBG with that of imipramine and reserpine suggests that menadione inhibits uptake 1 mediated uptake as well as granular storage.

AB - In this paper we report on our studies of the effect of menadione on the uptake of MIBG in the neuroendocrine cell lines PC12 and SIC-N-SH. Menadione inhibits the uptake of MIBG in both cell lines in a dose-dependent manner. Inhibition of MIBG uptake is most pronounced in the PC12 cell line. Comparison of the inhibitory action of menadione on the uptake and retention of MIBG with that of imipramine and reserpine suggests that menadione inhibits uptake 1 mediated uptake as well as granular storage.

KW - Menadione

KW - Meta-iodobenzylguanidine

KW - Neuroblastoma

KW - Oxidative stress

KW - Uptake

UR - https://www.scopus.com/pages/publications/0031050644

U2 - 10.1023/A:1005718421774

DO - 10.1023/A:1005718421774

M3 - Article

C2 - 9049842

AN - SCOPUS:0031050644

SN - 0167-594X

VL - 31

SP - 147

EP - 151

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

IS - 1-2

ER -

Menadione inhibits MIBG uptake in two neuroendocrine cell lines

Abstract

Keywords

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