Keyphrases
Methotrexate
100%
Childhood Acute Lymphoblastic Leukemia
100%
Treatment Outcome
100%
Methotrexate Resistance
100%
Acute Lymphoblastic Leukemia
81%
Leukemia Patients
45%
Leukemic Cells
18%
Metabolism
18%
Leukemia Therapy
18%
TEL-AML1
18%
Methotrexate Polyglutamates
18%
Reduced Folate Carrier
18%
Working Diagnosis
9%
Clinically Significant
9%
Molecular Mechanism
9%
Treatment Response
9%
Pediatric Acute Lymphoblastic Leukemia
9%
Clinical Characteristics
9%
Event-free Survival
9%
Clinical Data
9%
Novel Treatments
9%
Tumor Cells
9%
Cell Death
9%
DNA Replication
9%
High Accumulation
9%
MRNA Expression
9%
Delayed Diagnosis
9%
Drug Resistance
9%
Combination Chemotherapy
9%
Hyperdiploid
9%
Patient Identification
9%
Cytotoxic Agents
9%
Chemoresistance
9%
Clinical Differences
9%
Long-term Clinical Outcome
9%
Inhibition Assay
9%
Nucleotide Biosynthesis
9%
Concentration of Measure
9%
Chemotherapeutic Regimens
9%
Resistance Trends
9%
Low Accumulation
9%
Polyglutamate
9%
Curative Effect
9%
Medicine and Dentistry
Acute Lymphoblastic Leukemia
100%
Methotrexate
100%
Drug Resistance
11%
Methotrexate Polyglutamate
11%
Reduced Folate Carrier
11%
Pediatrics
5%
In Vitro
5%
Treatment Response
5%
Leukemia
5%
Event Free Survival
5%
Tumor Cell
5%
Cell Death
5%
Combination Chemotherapy
5%
Cytotoxic Agent
5%
DNA Synthesis
5%
Nucleotide Metabolism
5%
Polyglutamic Acid
5%
Chemotherapy
5%
Messenger RNA
5%
Pharmacology, Toxicology and Pharmaceutical Science
Methotrexate
100%
Acute Lymphoblastic Leukemia
100%
Chemotherapy
11%
Drug Resistance
11%
Methotrexate Polyglutamate
11%
Reduced Folate Carrier
11%
Neoplasm
5%
Event Free Survival
5%
Cytotoxic Agent
5%
Leukemia
5%
Polyglutamic Acid
5%
Messenger RNA
5%
Biochemistry, Genetics and Molecular Biology
Methotrexate
100%
Metabolic Pathway
10%
Drug Resistance
10%
Folic Acid
10%
Cell Death
5%
Event Free Survival
5%
Enzyme
5%
DNA Synthesis
5%
Nucleotide Metabolism
5%
Messenger RNA
5%
Immunology and Microbiology
Methotrexate
100%
Drug Resistance
10%
Tumor Cell
5%
Cell Death
5%
Event Free Survival
5%
DNA Synthesis
5%
Nucleotide Metabolism
5%