TY - JOUR
T1 - Micro-costing diagnostics in oncology
T2 - from single-gene testing to whole- genome sequencing
AU - Pasmans, Clémence T.B.
AU - Tops, Bastiaan B.J.
AU - Steeghs, Elisabeth M.P.
AU - Coupé, Veerle M.H.
AU - Grünberg, Katrien
AU - de Jong, Eiko K.
AU - Schuuring, Ed M.D.
AU - Willems, Stefan M.
AU - Ligtenberg, Marjolijn J.l.
AU - Retèl, Valesca P.
AU - van Snellenberg, Hans
AU - de Bruijn, Ewart
AU - Cuppen, Edwin
AU - Frederix, Geert W.J.
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Purpose: Predictive diagnostics play an increasingly important role in personalized medicine for cancer treatment. Whole-genome sequencing (WGS)-based treatment selection is expected to rapidly increase worldwide. This study aimed to calculate and compare the total cost of currently used diagnostic techniques and of WGS in treatment of non-small cell lung carcinoma (NSCLC), melanoma, colorectal cancer (CRC), and gastrointestinal stromal tumor (GIST) in the Netherlands. Methods: The activity-based costing (ABC) method was conducted to calculate total cost of included diagnostic techniques based on data provided by Dutch pathology laboratories and the Dutch-centralized cancer WGS facility. Costs were allocated to four categories: capital costs, maintenance costs, software costs, and operational costs. Results: The total cost per cancer patient per technique varied from € 58 (Sanger sequencing, three amplicons) to € 2925 (paired tumor-normal WGS). The operational costs accounted for the vast majority (over 90%) of the total per cancer patient technique costs. Conclusion: This study outlined in detail all costing aspects and cost prices of current and new diagnostic modalities used in treatment of NSCLC, melanoma, CRC, and GIST in the Netherlands. Detailed cost differences and value comparisons between these diagnostic techniques enable future economic evaluations to support decision-making.
AB - Purpose: Predictive diagnostics play an increasingly important role in personalized medicine for cancer treatment. Whole-genome sequencing (WGS)-based treatment selection is expected to rapidly increase worldwide. This study aimed to calculate and compare the total cost of currently used diagnostic techniques and of WGS in treatment of non-small cell lung carcinoma (NSCLC), melanoma, colorectal cancer (CRC), and gastrointestinal stromal tumor (GIST) in the Netherlands. Methods: The activity-based costing (ABC) method was conducted to calculate total cost of included diagnostic techniques based on data provided by Dutch pathology laboratories and the Dutch-centralized cancer WGS facility. Costs were allocated to four categories: capital costs, maintenance costs, software costs, and operational costs. Results: The total cost per cancer patient per technique varied from € 58 (Sanger sequencing, three amplicons) to € 2925 (paired tumor-normal WGS). The operational costs accounted for the vast majority (over 90%) of the total per cancer patient technique costs. Conclusion: This study outlined in detail all costing aspects and cost prices of current and new diagnostic modalities used in treatment of NSCLC, melanoma, CRC, and GIST in the Netherlands. Detailed cost differences and value comparisons between these diagnostic techniques enable future economic evaluations to support decision-making.
KW - Micro-costing
KW - oncology
KW - personalized medicine
KW - standard diagnostic techniques
KW - whole genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=85105444111&partnerID=8YFLogxK
U2 - 10.1080/14737167.2021.1917385
DO - 10.1080/14737167.2021.1917385
M3 - Article
C2 - 33852815
AN - SCOPUS:85105444111
SN - 1473-7167
VL - 21
SP - 413
EP - 414
JO - Expert Review of Pharmacoeconomics and Outcomes Research
JF - Expert Review of Pharmacoeconomics and Outcomes Research
IS - 3
ER -