Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F. Boj; Chang Il Hwang; Lindsey A. Baker; Dannielle D. Engle; David A. Tuveson; Hans Clevers

doi:10.1080/23723556.2015.1014757

Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F. Boj, Chang Il Hwang, Lindsey A. Baker, Dannielle D. Engle, David A. Tuveson, Hans Clevers

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

Original language	English
Article number	e1014757
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1014757
Publication status	Published - 2 Jan 2016
Externally published	Yes

Keywords

cancer
organoids
pancreatic ductal adenocarcinoma
preclinical models

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abstract = "We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.",

keywords = "cancer, organoids, pancreatic ductal adenocarcinoma, preclinical models",

author = "Boj, {Sylvia F.} and Hwang, {Chang Il} and Baker, {Lindsey A.} and Engle, {Dannielle D.} and Tuveson, {David A.} and Hans Clevers",

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AU - Tuveson, David A.

AU - Clevers, Hans

PY - 2016/1/2

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AB - We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

KW - cancer

KW - organoids

KW - pancreatic ductal adenocarcinoma

KW - preclinical models

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Model organoids provide new research opportunities for ductal pancreatic cancer

Abstract

Keywords

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