Modulation of glucocorticoid metabolism by the GH-IGF-I axis

Sebastian J.C.M.M. Neggers; Aart J. Van Der Lely

doi:10.1159/000321243

Modulation of glucocorticoid metabolism by the GH-IGF-I axis

Sebastian J.C.M.M. Neggers, Aart J. Van Der Lely

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

8 Citations (Scopus)

Abstract

Growth hormone (GH) can generate insulin-like growth factor-I production, provided that the liver encounters portal insulin as a permissive factor that switches on the liver sensitivity for GH. This phenomenon is important for a proper insight into the pathophysiology of diseases as type 1 and 2 diabetes which differ in portal insulin levels. Also, acromegaly and obesity can be better understood when this effect of insulin on liver sensitivity for GH is taken into account. Moreover, as all of these factors seem to influence activity of the 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 (and 2), an extensive knowledge on the interplay between them is crucial as nowadays treatment options for obesity using the 11β-HSD1 are emerging.

Original language	English
Title of host publication	Pediatric Adrenal Diseases
Editors	Lucia Ghizzoni, George Chrousos, Mohamad Maghnie, Marco Cappa, Sandro Loche
Pages	181-186
Number of pages	6
DOIs	https://doi.org/10.1159/000321243
Publication status	Published - Dec 2010
Externally published	Yes

Publication series

Name	Endocrine Development
Volume	20
ISSN (Print)	1421-7082
ISSN (Electronic)	1662-2979

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A2 - Loche, Sandro

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Modulation of glucocorticoid metabolism by the GH-IGF-I axis

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