Molecular mechanisms of 5-fluorocytosine resistance in yeasts and filamentous fungi

Fatima Zohra Delma, Abdullah M.S. Al-Hatmi, Roger J.M. Brüggemann, Willem J.G. Melchers, Sybren de Hoog, Paul E. Verweij, Jochem B. Buil

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.

Original languageEnglish
Article number909
JournalJournal of Fungi
Issue number11
Publication statusPublished - Nov 2021
Externally publishedYes


  • 5-fluorocytosine
  • Molecular mechanisms
  • Resistance


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