Molecular tools for the pathologic diagnosis of central nervous system tumors

Loudy P. Priesterbach-Ackley; Pieter Wesseling; Tom J. Snijders; Filip Y.F.L. De Vos; Wendy W.J. De Leng

doi:10.1093/nop/npy041

Molecular tools for the pathologic diagnosis of central nervous system tumors

Loudy P. Priesterbach-Ackley, Pieter Wesseling, Tom J. Snijders, Filip Y.F.L. De Vos, Wendy W.J. De Leng

Research related

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Molecular diagnostics currently has a crucial role in neuro-oncological patient care. (Epi)genetic assays testing for point mutations, copy number variations, gene fusions, translocations, and methylation status are of main diagnostic interest in neuro-oncology. Multiple assays have been developed for this purpose, ranging from single gene tests to high-Throughput, integrated techniques enabling detection of multiple genetic aberrations in a single workflow. This review describes the nature of the simpler and more complex assays for molecular diagnostics of tumors of the central nervous system and briefly discusses their strengths and weaknesses.

Original language	English
Pages (from-to)	4-16
Number of pages	13
Journal	Neuro-Oncology Practice
Volume	6
Issue number	1
DOIs	https://doi.org/10.1093/nop/npy041
Publication status	Published - 30 Jan 2019

Keywords

diagnosis
epigenetics
genetic alterations
molecular pathology
neuro-oncology

Access to Document

10.1093/nop/npy041

Cite this

@article{824b582b0bb44addbbfd7792d2c23a8e,

title = "Molecular tools for the pathologic diagnosis of central nervous system tumors",

abstract = "Molecular diagnostics currently has a crucial role in neuro-oncological patient care. (Epi)genetic assays testing for point mutations, copy number variations, gene fusions, translocations, and methylation status are of main diagnostic interest in neuro-oncology. Multiple assays have been developed for this purpose, ranging from single gene tests to high-Throughput, integrated techniques enabling detection of multiple genetic aberrations in a single workflow. This review describes the nature of the simpler and more complex assays for molecular diagnostics of tumors of the central nervous system and briefly discusses their strengths and weaknesses.",

keywords = "diagnosis, epigenetics, genetic alterations, molecular pathology, neuro-oncology",

author = "Priesterbach-Ackley, {Loudy P.} and Pieter Wesseling and Snijders, {Tom J.} and {De Vos}, {Filip Y.F.L.} and {De Leng}, {Wendy W.J.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected].",

year = "2019",

month = jan,

day = "30",

doi = "10.1093/nop/npy041",

language = "English",

volume = "6",

pages = "4--16",

journal = "Neuro-Oncology Practice",

issn = "2054-2577",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Molecular tools for the pathologic diagnosis of central nervous system tumors

AU - Priesterbach-Ackley, Loudy P.

AU - Wesseling, Pieter

AU - Snijders, Tom J.

AU - De Vos, Filip Y.F.L.

AU - De Leng, Wendy W.J.

N1 - Publisher Copyright: © The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected].

PY - 2019/1/30

Y1 - 2019/1/30

N2 - Molecular diagnostics currently has a crucial role in neuro-oncological patient care. (Epi)genetic assays testing for point mutations, copy number variations, gene fusions, translocations, and methylation status are of main diagnostic interest in neuro-oncology. Multiple assays have been developed for this purpose, ranging from single gene tests to high-Throughput, integrated techniques enabling detection of multiple genetic aberrations in a single workflow. This review describes the nature of the simpler and more complex assays for molecular diagnostics of tumors of the central nervous system and briefly discusses their strengths and weaknesses.

AB - Molecular diagnostics currently has a crucial role in neuro-oncological patient care. (Epi)genetic assays testing for point mutations, copy number variations, gene fusions, translocations, and methylation status are of main diagnostic interest in neuro-oncology. Multiple assays have been developed for this purpose, ranging from single gene tests to high-Throughput, integrated techniques enabling detection of multiple genetic aberrations in a single workflow. This review describes the nature of the simpler and more complex assays for molecular diagnostics of tumors of the central nervous system and briefly discusses their strengths and weaknesses.

KW - diagnosis

KW - epigenetics

KW - genetic alterations

KW - molecular pathology

KW - neuro-oncology

UR - http://www.scopus.com/inward/record.url?scp=85062401316&partnerID=8YFLogxK

U2 - 10.1093/nop/npy041

DO - 10.1093/nop/npy041

M3 - Article

AN - SCOPUS:85062401316

SN - 2054-2577

VL - 6

SP - 4

EP - 16

JO - Neuro-Oncology Practice

JF - Neuro-Oncology Practice

IS - 1

ER -

Molecular tools for the pathologic diagnosis of central nervous system tumors

Abstract

Keywords

Access to Document

Fingerprint

Cite this