Multi-antioxidant supplementation does not prevent an increase in gut permeability after lower torso ischemia and reperfusion in humans

M H W A Wijnen; H L Vader; R M H Roumen

doi:10.1159/000063072

Multi-antioxidant supplementation does not prevent an increase in gut permeability after lower torso ischemia and reperfusion in humans

M H W A Wijnen, H L Vader, R M H Roumen

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

BACKGROUND: An increase in gut permeability can have serious consequences leading to sepsis and multiple organ failure. After lower torso ischemia an increase in gut permeability is seen in both animals and humans. There is proof that this can be modified by antioxidant supplementation.

METHODS: In this prospective, randomized study we have looked at the influence of a multiantioxidant supplementation regime, using allopurinol, vitamins E and C, mannitol and N-acetylcysteine, perioperatively. Twenty-two patients received standard treatment and 20 patients received supplementation. Gut permeability was determined using a double sugar test with lactulose and rhamnose.

RESULTS: A significant increase in gut permeability was found neither in the non-treatment group (p = 0.012) nor in the treatment group (p = 0.006) after 6 and 24 h. No difference was found between the group receiving antioxidants and the standard treatment group. p = 0.93 6 h post clamp; p = 0.97 24 h post clamp.

CONCLUSION: In this study we have not found an influence of multiantioxidant supplementation on gut permeability after lower torso ischemia. Possible explanations for this negative result are being discussed.

Original language	English
Pages (from-to)	300-5
Number of pages	6
Journal	European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
Volume	34
Issue number	4
DOIs	https://doi.org/10.1159/000063072
Publication status	Published - 30 Jul 2002
Externally published	Yes

Keywords

Acetylcysteine/administration & dosage
Aged
Allopurinol/administration & dosage
Antimetabolites/administration & dosage
Antioxidants/administration & dosage
Aortic Aneurysm, Abdominal/surgery
Ascorbic Acid/administration & dosage
Diuretics, Osmotic/administration & dosage
Female
Free Radical Scavengers/administration & dosage
Humans
Intestinal Absorption/drug effects
Lactulose/pharmacokinetics
Male
Mannitol/administration & dosage
Middle Aged
Prospective Studies
Reperfusion Injury/drug therapy
Rhamnose/pharmacokinetics
Vitamin E/administration & dosage

Access to Document

10.1159/000063072

Cite this

@article{a34fb45d795c4fa1baf5b5a4876879ec,

title = "Multi-antioxidant supplementation does not prevent an increase in gut permeability after lower torso ischemia and reperfusion in humans",

abstract = "BACKGROUND: An increase in gut permeability can have serious consequences leading to sepsis and multiple organ failure. After lower torso ischemia an increase in gut permeability is seen in both animals and humans. There is proof that this can be modified by antioxidant supplementation.METHODS: In this prospective, randomized study we have looked at the influence of a multiantioxidant supplementation regime, using allopurinol, vitamins E and C, mannitol and N-acetylcysteine, perioperatively. Twenty-two patients received standard treatment and 20 patients received supplementation. Gut permeability was determined using a double sugar test with lactulose and rhamnose.RESULTS: A significant increase in gut permeability was found neither in the non-treatment group (p = 0.012) nor in the treatment group (p = 0.006) after 6 and 24 h. No difference was found between the group receiving antioxidants and the standard treatment group. p = 0.93 6 h post clamp; p = 0.97 24 h post clamp.CONCLUSION: In this study we have not found an influence of multiantioxidant supplementation on gut permeability after lower torso ischemia. Possible explanations for this negative result are being discussed.",

keywords = "Acetylcysteine/administration \& dosage, Aged, Allopurinol/administration \& dosage, Antimetabolites/administration \& dosage, Antioxidants/administration \& dosage, Aortic Aneurysm, Abdominal/surgery, Ascorbic Acid/administration \& dosage, Diuretics, Osmotic/administration \& dosage, Female, Free Radical Scavengers/administration \& dosage, Humans, Intestinal Absorption/drug effects, Lactulose/pharmacokinetics, Male, Mannitol/administration \& dosage, Middle Aged, Prospective Studies, Reperfusion Injury/drug therapy, Rhamnose/pharmacokinetics, Vitamin E/administration \& dosage",

author = "Wijnen, \{M H W A\} and Vader, \{H L\} and Roumen, \{R M H\}",

year = "2002",

month = jul,

day = "30",

doi = "10.1159/000063072",

language = "English",

volume = "34",

pages = "300--5",

journal = "European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes",

issn = "0014-312X",

publisher = "S. Karger AG",

number = "4",

}

Multi-antioxidant supplementation does not prevent an increase in gut permeability after lower torso ischemia and reperfusion in humans. / Wijnen, M H W A; Vader, H L; Roumen, R M H.
In: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, Vol. 34, No. 4, 30.07.2002, p. 300-5.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Multi-antioxidant supplementation does not prevent an increase in gut permeability after lower torso ischemia and reperfusion in humans

AU - Wijnen, M H W A

AU - Vader, H L

AU - Roumen, R M H

PY - 2002/7/30

Y1 - 2002/7/30

N2 - BACKGROUND: An increase in gut permeability can have serious consequences leading to sepsis and multiple organ failure. After lower torso ischemia an increase in gut permeability is seen in both animals and humans. There is proof that this can be modified by antioxidant supplementation.METHODS: In this prospective, randomized study we have looked at the influence of a multiantioxidant supplementation regime, using allopurinol, vitamins E and C, mannitol and N-acetylcysteine, perioperatively. Twenty-two patients received standard treatment and 20 patients received supplementation. Gut permeability was determined using a double sugar test with lactulose and rhamnose.RESULTS: A significant increase in gut permeability was found neither in the non-treatment group (p = 0.012) nor in the treatment group (p = 0.006) after 6 and 24 h. No difference was found between the group receiving antioxidants and the standard treatment group. p = 0.93 6 h post clamp; p = 0.97 24 h post clamp.CONCLUSION: In this study we have not found an influence of multiantioxidant supplementation on gut permeability after lower torso ischemia. Possible explanations for this negative result are being discussed.

AB - BACKGROUND: An increase in gut permeability can have serious consequences leading to sepsis and multiple organ failure. After lower torso ischemia an increase in gut permeability is seen in both animals and humans. There is proof that this can be modified by antioxidant supplementation.METHODS: In this prospective, randomized study we have looked at the influence of a multiantioxidant supplementation regime, using allopurinol, vitamins E and C, mannitol and N-acetylcysteine, perioperatively. Twenty-two patients received standard treatment and 20 patients received supplementation. Gut permeability was determined using a double sugar test with lactulose and rhamnose.RESULTS: A significant increase in gut permeability was found neither in the non-treatment group (p = 0.012) nor in the treatment group (p = 0.006) after 6 and 24 h. No difference was found between the group receiving antioxidants and the standard treatment group. p = 0.93 6 h post clamp; p = 0.97 24 h post clamp.CONCLUSION: In this study we have not found an influence of multiantioxidant supplementation on gut permeability after lower torso ischemia. Possible explanations for this negative result are being discussed.

KW - Acetylcysteine/administration & dosage

KW - Aged

KW - Allopurinol/administration & dosage

KW - Antimetabolites/administration & dosage

KW - Antioxidants/administration & dosage

KW - Aortic Aneurysm, Abdominal/surgery

KW - Ascorbic Acid/administration & dosage

KW - Diuretics, Osmotic/administration & dosage

KW - Female

KW - Free Radical Scavengers/administration & dosage

KW - Humans

KW - Intestinal Absorption/drug effects

KW - Lactulose/pharmacokinetics

KW - Male

KW - Mannitol/administration & dosage

KW - Middle Aged

KW - Prospective Studies

KW - Reperfusion Injury/drug therapy

KW - Rhamnose/pharmacokinetics

KW - Vitamin E/administration & dosage

UR - https://www.scopus.com/pages/publications/0036386908

U2 - 10.1159/000063072

DO - 10.1159/000063072

M3 - Article

C2 - 12145556

SN - 0014-312X

VL - 34

SP - 300

EP - 305

JO - European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

JF - European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

IS - 4

ER -

Multi-antioxidant supplementation does not prevent an increase in gut permeability after lower torso ischemia and reperfusion in humans

Abstract

Keywords

Access to Document

Fingerprint

Cite this