Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B

Filippo Arrigoni; Alberto De Luca; Daniele Velardo; Francesca Magri; Sandra Gandossini; Annamaria Russo; Martijn Froeling; Alessandra Bertoldo; Alexander Leemans; Nereo Bresolin; Grazia D'angelo

doi:10.1002/mus.26189

Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B

Filippo Arrigoni, Alberto De Luca, Daniele Velardo, Francesca Magri, Sandra Gandossini, Annamaria Russo, Martijn Froeling, Alessandra Bertoldo, Alexander Leemans, Nereo Bresolin, Grazia D'angelo

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Introduction: The aim of this study was to apply quantitative MRI (qMRI) to assess structural modifications in thigh muscles of subjects with limb girdle muscular dystrophy (LGMD) 2A and 2B with long disease duration. Methods: Eleven LGMD2A, 9 LGMD2B patients and 11 healthy controls underwent a multi-parametric 3T MRI examination of the thigh. The protocol included structural T1-weighted images, DIXON sequences for fat fraction calculation, T2 values quantification and diffusion MRI. Region of interest analysis was performed on 4 different compartments (anterior compartment, posterior compartment, gracilis, sartorius). Results: Patients showed high levels of fat infiltration as measured by DIXON sequences. Sartorius and anterior compartment were more infiltrated in LGMD2B than LGMD2A patients. T2 values were mildly reduced in both disorders. Correlations between clinical scores and qMRI were found. Conclusions: qMRI measures may help to quantify muscular degeneration, but careful interpretation is needed when fat infiltration is massive. Muscle Nerve 58: 550–558, 2018.

Original language	English
Pages (from-to)	550-558
Number of pages	9
Journal	Muscle and Nerve
Volume	58
Issue number	4
DOIs	https://doi.org/10.1002/mus.26189
Publication status	Published - Oct 2018
Externally published	Yes

Keywords

diffusion MRI
fat fraction
LGMD2A
LGMD2B
qMRI
T2 quantification

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title = "Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B",

abstract = "Introduction: The aim of this study was to apply quantitative MRI (qMRI) to assess structural modifications in thigh muscles of subjects with limb girdle muscular dystrophy (LGMD) 2A and 2B with long disease duration. Methods: Eleven LGMD2A, 9 LGMD2B patients and 11 healthy controls underwent a multi-parametric 3T MRI examination of the thigh. The protocol included structural T1-weighted images, DIXON sequences for fat fraction calculation, T2 values quantification and diffusion MRI. Region of interest analysis was performed on 4 different compartments (anterior compartment, posterior compartment, gracilis, sartorius). Results: Patients showed high levels of fat infiltration as measured by DIXON sequences. Sartorius and anterior compartment were more infiltrated in LGMD2B than LGMD2A patients. T2 values were mildly reduced in both disorders. Correlations between clinical scores and qMRI were found. Conclusions: qMRI measures may help to quantify muscular degeneration, but careful interpretation is needed when fat infiltration is massive. Muscle Nerve 58: 550–558, 2018.",

keywords = "diffusion MRI, fat fraction, LGMD2A, LGMD2B, qMRI, T2 quantification",

author = "Filippo Arrigoni and {De Luca}, Alberto and Daniele Velardo and Francesca Magri and Sandra Gandossini and Annamaria Russo and Martijn Froeling and Alessandra Bertoldo and Alexander Leemans and Nereo Bresolin and Grazia D'angelo",

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year = "2018",

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doi = "10.1002/mus.26189",

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AU - Arrigoni, Filippo

AU - De Luca, Alberto

AU - Velardo, Daniele

AU - Magri, Francesca

AU - Gandossini, Sandra

AU - Russo, Annamaria

AU - Froeling, Martijn

AU - Bertoldo, Alessandra

AU - Leemans, Alexander

AU - Bresolin, Nereo

AU - D'angelo, Grazia

PY - 2018/10

Y1 - 2018/10

N2 - Introduction: The aim of this study was to apply quantitative MRI (qMRI) to assess structural modifications in thigh muscles of subjects with limb girdle muscular dystrophy (LGMD) 2A and 2B with long disease duration. Methods: Eleven LGMD2A, 9 LGMD2B patients and 11 healthy controls underwent a multi-parametric 3T MRI examination of the thigh. The protocol included structural T1-weighted images, DIXON sequences for fat fraction calculation, T2 values quantification and diffusion MRI. Region of interest analysis was performed on 4 different compartments (anterior compartment, posterior compartment, gracilis, sartorius). Results: Patients showed high levels of fat infiltration as measured by DIXON sequences. Sartorius and anterior compartment were more infiltrated in LGMD2B than LGMD2A patients. T2 values were mildly reduced in both disorders. Correlations between clinical scores and qMRI were found. Conclusions: qMRI measures may help to quantify muscular degeneration, but careful interpretation is needed when fat infiltration is massive. Muscle Nerve 58: 550–558, 2018.

AB - Introduction: The aim of this study was to apply quantitative MRI (qMRI) to assess structural modifications in thigh muscles of subjects with limb girdle muscular dystrophy (LGMD) 2A and 2B with long disease duration. Methods: Eleven LGMD2A, 9 LGMD2B patients and 11 healthy controls underwent a multi-parametric 3T MRI examination of the thigh. The protocol included structural T1-weighted images, DIXON sequences for fat fraction calculation, T2 values quantification and diffusion MRI. Region of interest analysis was performed on 4 different compartments (anterior compartment, posterior compartment, gracilis, sartorius). Results: Patients showed high levels of fat infiltration as measured by DIXON sequences. Sartorius and anterior compartment were more infiltrated in LGMD2B than LGMD2A patients. T2 values were mildly reduced in both disorders. Correlations between clinical scores and qMRI were found. Conclusions: qMRI measures may help to quantify muscular degeneration, but careful interpretation is needed when fat infiltration is massive. Muscle Nerve 58: 550–558, 2018.

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Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B

Abstract

Keywords

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