Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia

Andrica C.H. De Vries; Ronald W. Stam; Christian P. Kratz; Martin Zenker; Charlotte M. Niemeyer; Marry M. Van Den Heuvel-Eibrink

doi:10.3324/haematol.11493

Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia

Andrica C.H. De Vries
, Ronald W. Stam
, Christian P. Kratz
, Martin Zenker
, Charlotte M. Niemeyer
, Marry M. Van Den Heuvel-Eibrink

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

Original language	English
Pages (from-to)	1574-1575
Number of pages	2
Journal	Haematologica
Volume	92
Issue number	11
DOIs	https://doi.org/10.3324/haematol.11493
Publication status	Published - Nov 2007
Externally published	Yes

Keywords

BRAF
Juvenile myelomonocytic leukemia

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10.3324/haematol.11493

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title = "Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia",

abstract = "Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.",

keywords = "BRAF, Juvenile myelomonocytic leukemia",

author = "\{De Vries\}, \{Andrica C.H.\} and Stam, \{Ronald W.\} and Kratz, \{Christian P.\} and Martin Zenker and Niemeyer, \{Charlotte M.\} and \{Van Den Heuvel-Eibrink\}, \{Marry M.\}",

year = "2007",

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AU - De Vries, Andrica C.H.

AU - Stam, Ronald W.

AU - Kratz, Christian P.

AU - Zenker, Martin

AU - Niemeyer, Charlotte M.

AU - Van Den Heuvel-Eibrink, Marry M.

PY - 2007/11

Y1 - 2007/11

N2 - Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

AB - Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

KW - BRAF

KW - Juvenile myelomonocytic leukemia

UR - https://www.scopus.com/pages/publications/36348986709

U2 - 10.3324/haematol.11493

DO - 10.3324/haematol.11493

M3 - Article

C2 - 18024410

AN - SCOPUS:36348986709

SN - 0390-6078

VL - 92

SP - 1574

EP - 1575

JO - Haematologica

JF - Haematologica

IS - 11

ER -

Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia

Abstract

Keywords

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