TY - JOUR
T1 - Myocardial strain and strain rate in monitoring subclinical heart failure in asymptomatic long-term survivors of childhood cancer
AU - Mavinkurve-Groothuis, Annelies M.C.
AU - Groot-Loonen, Jacqueline
AU - Marcus, Karen A.
AU - Bellersen, Louise
AU - Feuth, Ton
AU - Bökkerink, Jos P.M.
AU - Hoogerbrugge, Peter M.
AU - de Korte, Chris
AU - Kapusta, Livia
N1 - Funding Information:
The authors kindly thank Milanthy Pourier, Gert Weijers, Bob Rijk, Imke Tomasouw-Janssen, Marian Zwartjes and Romana d’Ancona for their help in obtaining the strain data. This study was supported by the Foundation of Childhood Cancer Nijmegen (“Stichting Vrienden KOC”) .
PY - 2010/11
Y1 - 2010/11
N2 - We studied the role of global myocardial strain and strain rate in monitoring subclinical heart failure in a large group of asymptomatic long-term survivors of childhood cancer. Global strain (rate) parameters of survivors were compared with those in healthy controls and were related to conventional echocardiographic parameters, N-terminal-pro-natriuretic peptide (NT-pro-BNP) levels and clinical parameters. Two-dimensional (2-D) echocardiography was performed in 111 survivors and 107 healthy controls. Blood samples were taken from survivors to determine NT-pro-BNP levels. We showed that global myocardial strain, strain rate and time to peak systolic strain in asymptomatic survivors of childhood cancer were significantly lower compared with healthy controls (p values <0.0001) and were significantly related to several systolic and diastolic left ventricular parameters. Whether myocardial strain and strain rate are superior to conventional echocardiography in the early detection of subclinical heart failure needs to be explored in further longitudinal prospective studies.
AB - We studied the role of global myocardial strain and strain rate in monitoring subclinical heart failure in a large group of asymptomatic long-term survivors of childhood cancer. Global strain (rate) parameters of survivors were compared with those in healthy controls and were related to conventional echocardiographic parameters, N-terminal-pro-natriuretic peptide (NT-pro-BNP) levels and clinical parameters. Two-dimensional (2-D) echocardiography was performed in 111 survivors and 107 healthy controls. Blood samples were taken from survivors to determine NT-pro-BNP levels. We showed that global myocardial strain, strain rate and time to peak systolic strain in asymptomatic survivors of childhood cancer were significantly lower compared with healthy controls (p values <0.0001) and were significantly related to several systolic and diastolic left ventricular parameters. Whether myocardial strain and strain rate are superior to conventional echocardiography in the early detection of subclinical heart failure needs to be explored in further longitudinal prospective studies.
KW - 2-D echocardiography
KW - Anthracycline-induced cardiotoxicity
KW - Childhood cancer
KW - Late-onset cardiotoxicity
KW - Myocardial strain
UR - http://www.scopus.com/inward/record.url?scp=77958151957&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2010.08.001
DO - 10.1016/j.ultrasmedbio.2010.08.001
M3 - Article
C2 - 20870348
AN - SCOPUS:77958151957
SN - 0301-5629
VL - 36
SP - 1783
EP - 1791
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 11
ER -