Myocyte enhancer factor 2C in hematopoiesis and leukemia

K. Canté-Barrett; R. Pieters; J. P.P. Meijerink

doi:10.1038/onc.2013.56

Myocyte enhancer factor 2C in hematopoiesis and leukemia

K. Canté-Barrett, R. Pieters, J. P.P. Meijerink

Research output: Contribution to journal › Review article › peer-review

69 Citations (Scopus)

Abstract

MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.

Original language	English
Pages (from-to)	403-410
Number of pages	8
Journal	Oncogene
Volume	33
Issue number	4
DOIs	https://doi.org/10.1038/onc.2013.56
Publication status	Published - 23 Jan 2014
Externally published	Yes

Keywords

Hematopoiesis
Leukemia
MEF2C

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title = "Myocyte enhancer factor 2C in hematopoiesis and leukemia",

abstract = "MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.",

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author = "K. Cant{\'e}-Barrett and R. Pieters and Meijerink, {J. P.P.}",

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AU - Pieters, R.

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AB - MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.

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KW - Leukemia

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Myocyte enhancer factor 2C in hematopoiesis and leukemia

Abstract

Keywords

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