No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

Anne E. Bras; Marry M. Van den Heuvel-Eibrink; Alita J. Van der Sluijs-Gelling; Eva A. Coenen; Henk Wind; C. Michel Zwaan; Jeroen G. Te Marvelde; Mirjam Van der Burg; Brenda Gibson; Anita W. Rijneveld; Valérie De Haas; Jacques J.M. Van Dongen; Vincent H.J. Van der Velden

doi:10.1111/bjh.12329

No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

Anne E. Bras
, Marry M. Van den Heuvel-Eibrink
, Alita J. Van der Sluijs-Gelling
, Eva A. Coenen
, Henk Wind
, C. Michel Zwaan
, Jeroen G. Te Marvelde
, Mirjam Van der Burg
, Brenda Gibson
, Anita W. Rijneveld
, Valérie De Haas
, Jacques J.M. Van Dongen
, Vincent H.J. Van der Velden

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.

Original language	English
Pages (from-to)	861-864
Number of pages	4
Journal	British journal of haematology
Volume	161
Issue number	6
DOIs	https://doi.org/10.1111/bjh.12329
Publication status	Published - Jun 2013
Externally published	Yes

Keywords

AML
B-cells
MRD
Paediatric
Relapse

Access to Document

10.1111/bjh.12329

Cite this

Bras, A. E., Van den Heuvel-Eibrink, M. M., Van der Sluijs-Gelling, A. J., Coenen, E. A., Wind, H., Zwaan, C. M., Te Marvelde, J. G., Van der Burg, M., Gibson, B., Rijneveld, A. W., De Haas, V., Van Dongen, J. J. M., & Van der Velden, V. H. J. (2013). No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment. British journal of haematology, 161(6), 861-864. https://doi.org/10.1111/bjh.12329

@article{f847b01d935f447a99e83dfab70ff517,

title = "No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment",

abstract = "B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81\% of 59 paediatric AML patients at first complete remission; this compared to 46\% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.",

keywords = "AML, B-cells, MRD, Paediatric, Relapse",

author = "Bras, \{Anne E.\} and \{Van den Heuvel-Eibrink\}, \{Marry M.\} and \{Van der Sluijs-Gelling\}, \{Alita J.\} and Coenen, \{Eva A.\} and Henk Wind and Zwaan, \{C. Michel\} and \{Te Marvelde\}, \{Jeroen G.\} and \{Van der Burg\}, Mirjam and Brenda Gibson and Rijneveld, \{Anita W.\} and \{De Haas\}, Val{\'e}rie and \{Van Dongen\}, \{Jacques J.M.\} and \{Van der Velden\}, \{Vincent H.J.\}",

year = "2013",

month = jun,

doi = "10.1111/bjh.12329",

language = "English",

volume = "161",

pages = "861--864",

journal = "British journal of haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

Bras, AE, Van den Heuvel-Eibrink, MM, Van der Sluijs-Gelling, AJ, Coenen, EA, Wind, H, Zwaan, CM, Te Marvelde, JG, Van der Burg, M, Gibson, B, Rijneveld, AW, De Haas, V, Van Dongen, JJM & Van der Velden, VHJ 2013, 'No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment', British journal of haematology, vol. 161, no. 6, pp. 861-864. https://doi.org/10.1111/bjh.12329

TY - JOUR

T1 - No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

AU - Bras, Anne E.

AU - Van den Heuvel-Eibrink, Marry M.

AU - Van der Sluijs-Gelling, Alita J.

AU - Coenen, Eva A.

AU - Wind, Henk

AU - Zwaan, C. Michel

AU - Te Marvelde, Jeroen G.

AU - Van der Burg, Mirjam

AU - Gibson, Brenda

AU - Rijneveld, Anita W.

AU - De Haas, Valérie

AU - Van Dongen, Jacques J.M.

AU - Van der Velden, Vincent H.J.

PY - 2013/6

Y1 - 2013/6

N2 - B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.

AB - B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.

KW - AML

KW - B-cells

KW - MRD

KW - Paediatric

KW - Relapse

UR - https://www.scopus.com/pages/publications/84878487145

U2 - 10.1111/bjh.12329

DO - 10.1111/bjh.12329

M3 - Article

C2 - 23577982

AN - SCOPUS:84878487145

SN - 0007-1048

VL - 161

SP - 861

EP - 864

JO - British journal of haematology

JF - British journal of haematology

IS - 6

ER -

No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

Abstract

Keywords

Access to Document

Fingerprint

Cite this