Non-coding transcription by RNA polymerase II in yeast: Hasard or nécessité?

Agnieszka Tudek; Tito Candelli; Domenico Libri

doi:10.1016/j.biochi.2015.04.020

Non-coding transcription by RNA polymerase II in yeast: Hasard or nécessité?

Agnieszka Tudek, Tito Candelli, Domenico Libri

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

Recent developments of microarrays and deep sequencing techniques have unveiled an unexpected complexity of the eukaryotic transcriptome, demonstrating that virtualy the entire genome is transcribed by RNA polymerase II (RNAPII). Transcription occurring outside of annotated regions is generally referred to as pervasive transcription and leads to the production of several classes of non-coding RNAs (ncRNAs). In this review we will discuss the metabolism and functional significance of these ncRNAs in the yeast Saccharomyces cerevisiae. We will discuss the mechanisms that the cell has adopted to prevent potentially disruptive interference between pervasive transcription and the expression of canonical genes. We will explore the possible reasons that justify the evolutionary conserved maintenance of extensive genomic transcription.

Original language	English
Pages (from-to)	28-36
Number of pages	9
Journal	Biochimie
Volume	117
DOIs	https://doi.org/10.1016/j.biochi.2015.04.020
Publication status	Published - 1 Oct 2015
Externally published	Yes

Keywords

CPF-CF
ncRNAs
NNS
Pervasive transcription
RNA degradation
Road-block

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10.1016/j.biochi.2015.04.020

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title = "Non-coding transcription by RNA polymerase II in yeast: Hasard or n{\'e}cessit{\'e}?",

abstract = "Recent developments of microarrays and deep sequencing techniques have unveiled an unexpected complexity of the eukaryotic transcriptome, demonstrating that virtualy the entire genome is transcribed by RNA polymerase II (RNAPII). Transcription occurring outside of annotated regions is generally referred to as pervasive transcription and leads to the production of several classes of non-coding RNAs (ncRNAs). In this review we will discuss the metabolism and functional significance of these ncRNAs in the yeast Saccharomyces cerevisiae. We will discuss the mechanisms that the cell has adopted to prevent potentially disruptive interference between pervasive transcription and the expression of canonical genes. We will explore the possible reasons that justify the evolutionary conserved maintenance of extensive genomic transcription.",

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T2 - Hasard or nécessité?

AU - Tudek, Agnieszka

AU - Candelli, Tito

AU - Libri, Domenico

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Recent developments of microarrays and deep sequencing techniques have unveiled an unexpected complexity of the eukaryotic transcriptome, demonstrating that virtualy the entire genome is transcribed by RNA polymerase II (RNAPII). Transcription occurring outside of annotated regions is generally referred to as pervasive transcription and leads to the production of several classes of non-coding RNAs (ncRNAs). In this review we will discuss the metabolism and functional significance of these ncRNAs in the yeast Saccharomyces cerevisiae. We will discuss the mechanisms that the cell has adopted to prevent potentially disruptive interference between pervasive transcription and the expression of canonical genes. We will explore the possible reasons that justify the evolutionary conserved maintenance of extensive genomic transcription.

AB - Recent developments of microarrays and deep sequencing techniques have unveiled an unexpected complexity of the eukaryotic transcriptome, demonstrating that virtualy the entire genome is transcribed by RNA polymerase II (RNAPII). Transcription occurring outside of annotated regions is generally referred to as pervasive transcription and leads to the production of several classes of non-coding RNAs (ncRNAs). In this review we will discuss the metabolism and functional significance of these ncRNAs in the yeast Saccharomyces cerevisiae. We will discuss the mechanisms that the cell has adopted to prevent potentially disruptive interference between pervasive transcription and the expression of canonical genes. We will explore the possible reasons that justify the evolutionary conserved maintenance of extensive genomic transcription.

KW - CPF-CF

KW - ncRNAs

KW - NNS

KW - Pervasive transcription

KW - RNA degradation

KW - Road-block

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DO - 10.1016/j.biochi.2015.04.020

M3 - Review article

C2 - 25956976

AN - SCOPUS:84941601251

SN - 0300-9084

VL - 117

SP - 28

EP - 36

JO - Biochimie

JF - Biochimie

ER -

Non-coding transcription by RNA polymerase II in yeast: Hasard or nécessité?

Abstract

Keywords

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