Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy

A. J.H. Suurmeijer; J. W. Oosterhuis; J. Marrink; H. W. De Bruin; H. Schraffordt Koops; D. T. Sleijfer; G. J. Fleuren

Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy

A. J.H. Suurmeijer
, J. W. Oosterhuis
, J. Marrink
, H. W. De Bruin
, H. Schraffordt Koops
, D. T. Sleijfer
, G. J. Fleuren

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Serum AFP and HCG values were correlated with AFP and HCG tissue staining in 27 non-seminomatous germ cell tumors (NSGCT) of the testis and their retroperitoneal lymph node metastases after PVB chemotherapy. We found a poor correlation between tissue and serum AFP positivity and a moderately good correlation between tissue and serum HCG positivity in the testicular tumor. The therapy-related differentiated teratomatous elements did occasionally produce AFP or HCG, but AFP or HCG were not detectable in the patient's sera. These serum markers have no value for the detection of mature residual tumor following chemotherapy.

Original language	English
Pages (from-to)	289-308
Number of pages	20
Journal	Oncodevelopmental Biology and Medicine
Volume	4
Issue number	4
Publication status	Published - 1983
Externally published	Yes

Cite this

Suurmeijer, A. J. H., Oosterhuis, J. W., Marrink, J., De Bruin, H. W., Schraffordt Koops, H., Sleijfer, D. T., & Fleuren, G. J. (1983). Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy. Oncodevelopmental Biology and Medicine, 4(4), 289-308.

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title = "Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy",

abstract = "Serum AFP and HCG values were correlated with AFP and HCG tissue staining in 27 non-seminomatous germ cell tumors (NSGCT) of the testis and their retroperitoneal lymph node metastases after PVB chemotherapy. We found a poor correlation between tissue and serum AFP positivity and a moderately good correlation between tissue and serum HCG positivity in the testicular tumor. The therapy-related differentiated teratomatous elements did occasionally produce AFP or HCG, but AFP or HCG were not detectable in the patient's sera. These serum markers have no value for the detection of mature residual tumor following chemotherapy.",

author = "Suurmeijer, \{A. J.H.\} and Oosterhuis, \{J. W.\} and J. Marrink and \{De Bruin\}, \{H. W.\} and \{Schraffordt Koops\}, H. and Sleijfer, \{D. T.\} and Fleuren, \{G. J.\}",

year = "1983",

language = "English",

volume = "4",

pages = "289--308",

journal = "Oncodevelopmental Biology and Medicine",

issn = "0167-1618",

publisher = "S. Karger AG",

number = "4",

}

Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy. / Suurmeijer, A. J.H.; Oosterhuis, J. W.; Marrink, J. et al.
In: Oncodevelopmental Biology and Medicine, Vol. 4, No. 4, 1983, p. 289-308.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy

AU - Suurmeijer, A. J.H.

AU - Oosterhuis, J. W.

AU - Marrink, J.

AU - De Bruin, H. W.

AU - Schraffordt Koops, H.

AU - Sleijfer, D. T.

AU - Fleuren, G. J.

PY - 1983

Y1 - 1983

N2 - Serum AFP and HCG values were correlated with AFP and HCG tissue staining in 27 non-seminomatous germ cell tumors (NSGCT) of the testis and their retroperitoneal lymph node metastases after PVB chemotherapy. We found a poor correlation between tissue and serum AFP positivity and a moderately good correlation between tissue and serum HCG positivity in the testicular tumor. The therapy-related differentiated teratomatous elements did occasionally produce AFP or HCG, but AFP or HCG were not detectable in the patient's sera. These serum markers have no value for the detection of mature residual tumor following chemotherapy.

AB - Serum AFP and HCG values were correlated with AFP and HCG tissue staining in 27 non-seminomatous germ cell tumors (NSGCT) of the testis and their retroperitoneal lymph node metastases after PVB chemotherapy. We found a poor correlation between tissue and serum AFP positivity and a moderately good correlation between tissue and serum HCG positivity in the testicular tumor. The therapy-related differentiated teratomatous elements did occasionally produce AFP or HCG, but AFP or HCG were not detectable in the patient's sera. These serum markers have no value for the detection of mature residual tumor following chemotherapy.

UR - https://www.scopus.com/pages/publications/0020582194

M3 - Article

C2 - 6188132

AN - SCOPUS:0020582194

SN - 0167-1618

VL - 4

SP - 289

EP - 308

JO - Oncodevelopmental Biology and Medicine

JF - Oncodevelopmental Biology and Medicine

IS - 4

ER -

Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy

Abstract

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