Non-seminomatous germ cell tumors of the testis. Analysis of CEA production in primary tumors and in retroperitoneal lymph node metastases after PVB chemotherapy

A. J.H. Suurmeijer; J. W. Oosterhuis; J. Marrink; TH Ockhuizen; D. TH Sleijfer; H. Schraffordt Koops; G. J. Fleuren

doi:10.1016/0277-5379(84)90004-X

Non-seminomatous germ cell tumors of the testis. Analysis of CEA production in primary tumors and in retroperitoneal lymph node metastases after PVB chemotherapy

A. J.H. Suurmeijer, J. W. Oosterhuis, J. Marrink, TH Ockhuizen, D. TH Sleijfer, H. Schraffordt Koops, G. J. Fleuren

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6 Citations (Scopus)

Abstract

In the present investigation we compared CEA immunoperoxidase staining in testicular tumors (before PVB chemotherapy) and retroperitoneal tumors (after PVB chemotherapy) with CEA levels in the cyst fluid of retroperitoneal mature teratoma and in the patients' serum. CEA had no value as a serum tumor marker since serum CEA elevations were not associated with tumor activity. Only one elevated CEA level after chemotherapy was associated with bleomycin pneumonitis. Despite normal serum levels, CEA was localized immunohistochemically in yolk sac tumor and mature teratoma in the primary tumors and in retroperitoneal mature teratoma following PVB chemotherapy. The presence of CEA in cells lining cystic mature teratoma was associated with high CEA levels in the cyst fluid.

Original language	English
Pages (from-to)	601-608
Number of pages	8
Journal	European Journal of Cancer and Clinical Oncology
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/0277-5379(84)90004-X
Publication status	Published - May 1984
Externally published	Yes

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Suurmeijer, A. J. H., Oosterhuis, J. W., Marrink, J., Ockhuizen, TH., Sleijfer, D. TH., Schraffordt Koops, H., & Fleuren, G. J. (1984). Non-seminomatous germ cell tumors of the testis. Analysis of CEA production in primary tumors and in retroperitoneal lymph node metastases after PVB chemotherapy. European Journal of Cancer and Clinical Oncology, 20(5), 601-608. https://doi.org/10.1016/0277-5379(84)90004-X

@article{468b037ef1fb40edb30d8599a88323f7,

title = "Non-seminomatous germ cell tumors of the testis. Analysis of CEA production in primary tumors and in retroperitoneal lymph node metastases after PVB chemotherapy",

abstract = "In the present investigation we compared CEA immunoperoxidase staining in testicular tumors (before PVB chemotherapy) and retroperitoneal tumors (after PVB chemotherapy) with CEA levels in the cyst fluid of retroperitoneal mature teratoma and in the patients' serum. CEA had no value as a serum tumor marker since serum CEA elevations were not associated with tumor activity. Only one elevated CEA level after chemotherapy was associated with bleomycin pneumonitis. Despite normal serum levels, CEA was localized immunohistochemically in yolk sac tumor and mature teratoma in the primary tumors and in retroperitoneal mature teratoma following PVB chemotherapy. The presence of CEA in cells lining cystic mature teratoma was associated with high CEA levels in the cyst fluid.",

author = "Suurmeijer, {A. J.H.} and Oosterhuis, {J. W.} and J. Marrink and TH Ockhuizen and Sleijfer, {D. TH} and {Schraffordt Koops}, H. and Fleuren, {G. J.}",

note = "Funding Information: Accepted 3 November 1983. *This study was supported by grant GUKC, 81-4 from the Koningin Wilhelmina Fonds, The Netherlands Cancer Foundation.",

year = "1984",

month = may,

doi = "10.1016/0277-5379(84)90004-X",

language = "English",

volume = "20",

pages = "601--608",

journal = "European Journal of Cancer and Clinical Oncology",

issn = "0277-5379",

publisher = "Pergamon Press",

number = "5",

}

Suurmeijer, AJH, Oosterhuis, JW, Marrink, J, Ockhuizen, TH, Sleijfer, DTH, Schraffordt Koops, H & Fleuren, GJ 1984, 'Non-seminomatous germ cell tumors of the testis. Analysis of CEA production in primary tumors and in retroperitoneal lymph node metastases after PVB chemotherapy', European Journal of Cancer and Clinical Oncology, vol. 20, no. 5, pp. 601-608. https://doi.org/10.1016/0277-5379(84)90004-X

Non-seminomatous germ cell tumors of the testis. Analysis of CEA production in primary tumors and in retroperitoneal lymph node metastases after PVB chemotherapy. / Suurmeijer, A. J.H.; Oosterhuis, J. W.; Marrink, J. et al.
In: European Journal of Cancer and Clinical Oncology, Vol. 20, No. 5, 05.1984, p. 601-608.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Non-seminomatous germ cell tumors of the testis. Analysis of CEA production in primary tumors and in retroperitoneal lymph node metastases after PVB chemotherapy

AU - Suurmeijer, A. J.H.

AU - Oosterhuis, J. W.

AU - Marrink, J.

AU - Ockhuizen, TH

AU - Sleijfer, D. TH

AU - Schraffordt Koops, H.

AU - Fleuren, G. J.

N1 - Funding Information: Accepted 3 November 1983. *This study was supported by grant GUKC, 81-4 from the Koningin Wilhelmina Fonds, The Netherlands Cancer Foundation.

PY - 1984/5

Y1 - 1984/5

N2 - In the present investigation we compared CEA immunoperoxidase staining in testicular tumors (before PVB chemotherapy) and retroperitoneal tumors (after PVB chemotherapy) with CEA levels in the cyst fluid of retroperitoneal mature teratoma and in the patients' serum. CEA had no value as a serum tumor marker since serum CEA elevations were not associated with tumor activity. Only one elevated CEA level after chemotherapy was associated with bleomycin pneumonitis. Despite normal serum levels, CEA was localized immunohistochemically in yolk sac tumor and mature teratoma in the primary tumors and in retroperitoneal mature teratoma following PVB chemotherapy. The presence of CEA in cells lining cystic mature teratoma was associated with high CEA levels in the cyst fluid.

AB - In the present investigation we compared CEA immunoperoxidase staining in testicular tumors (before PVB chemotherapy) and retroperitoneal tumors (after PVB chemotherapy) with CEA levels in the cyst fluid of retroperitoneal mature teratoma and in the patients' serum. CEA had no value as a serum tumor marker since serum CEA elevations were not associated with tumor activity. Only one elevated CEA level after chemotherapy was associated with bleomycin pneumonitis. Despite normal serum levels, CEA was localized immunohistochemically in yolk sac tumor and mature teratoma in the primary tumors and in retroperitoneal mature teratoma following PVB chemotherapy. The presence of CEA in cells lining cystic mature teratoma was associated with high CEA levels in the cyst fluid.

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JO - European Journal of Cancer and Clinical Oncology

JF - European Journal of Cancer and Clinical Oncology

IS - 5

ER -

Non-seminomatous germ cell tumors of the testis. Analysis of CEA production in primary tumors and in retroperitoneal lymph node metastases after PVB chemotherapy

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