Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease

Johan H. Van Es, Hans Clevers

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Colorectal cancer is a major cause of death in the western world. Recent advances in treatment comprise variations on the classical themes of surgical resection combined with chemotherapy using cytotoxic drugs and radiation therapy. Because this therapy is only moderately successful, novel approaches to the treatment of colorectal cancer are required. Our rapidly increasing knowledge of molecular signalling pathways that are deregulated in colorectal cancer might provide a platform from which to develop new rational cancer therapies. Here, we give an update on the roles of the Wnt and Notch signalling pathways in the self renewal of the intestinal epithelium and the consequences of Wnt deregulation in colorectal cancer. We focus on the potential of recently identified small-molecule inhibitors of the Wnt pathway and γ-secretase inhibitors of the Notch pathway as novel colon cancer therapeutics.

Original languageEnglish
Pages (from-to)496-502
Number of pages7
JournalTrends in Molecular Medicine
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2005
Externally publishedYes

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