TY - JOUR
T1 - Nucleotide excision repair I
T2 - from E. coli to yeast
AU - Hoeijmakers, Jan H.J.
N1 - Funding Information:
I apologize to those whose important primary papers were not cited due to space restrictions. I thank all my colleagues in the DNA repair group of the Medical Genetics Centre for valuable discussions, and other colleagues in the field for sharing unpublished results, and R. Boucke for typing the manuscript. Research in our group is supported by the Netherlands Organization for the Advancement of Pure Science, through the Foundation of Medical Scientific Research, the Dutch Cancer Society and Euratom.
PY - 1993/5
Y1 - 1993/5
N2 - Genetic information is constantly deteriorating, mainly as a consequence of the action of numerous genotoxic agents. In order to cope with this fundamental problem, all living organisms have acquired a complex network of DNA repair systems to safeguard their genetic integrity. Nucleotide excision repair (NER), one of the most important of these, is a complex multi-enzyme reaction that removes a remarkably wide range of lesions. This is the first of a series of two reviews on this repair process. Part I focuses on the main characteristics of the NER pathway in E. coli and yeast. Part II, to appear in the next issue of TIG, deals with NER in mammals and compares it with the process in yeast.
AB - Genetic information is constantly deteriorating, mainly as a consequence of the action of numerous genotoxic agents. In order to cope with this fundamental problem, all living organisms have acquired a complex network of DNA repair systems to safeguard their genetic integrity. Nucleotide excision repair (NER), one of the most important of these, is a complex multi-enzyme reaction that removes a remarkably wide range of lesions. This is the first of a series of two reviews on this repair process. Part I focuses on the main characteristics of the NER pathway in E. coli and yeast. Part II, to appear in the next issue of TIG, deals with NER in mammals and compares it with the process in yeast.
UR - http://www.scopus.com/inward/record.url?scp=0027310880&partnerID=8YFLogxK
U2 - 10.1016/0168-9525(93)90164-D
DO - 10.1016/0168-9525(93)90164-D
M3 - Review article
C2 - 8337754
AN - SCOPUS:0027310880
SN - 0168-9525
VL - 9
SP - 173
EP - 177
JO - Trends in Genetics
JF - Trends in Genetics
IS - 5
ER -