Nutrition during trimodality treatment in stage III non-small cell lung cancer: Not only important for underweight patients

Barbara S. Van Der Meij, Erik C.J. Phernambucq, Geert M. Fieten, Egbert F. Smit, Marinus A. Paul, Paul A.M. Van Leeuwen, J. Wolter A. Oosterhuis

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Trimodality treatment for stage III non-small cell lung cancer (NSCLC), consisting of chemoradiotherapy followed by surgery, is associated with treatment-related toxicity, malnutrition, and postoperative complications. The aim of this retrospective study was to investigate the predictive value of nutritional parameters on postoperative morbidity, mortality, and survival. Methods: Patients with stage III NSCLC undergoing concurrent chemoradiotherapy followed by surgery in one center between 2003 and 2009 were included. Age, sex, forced expiratory volume in 1 second, body mass index, weight change, and surgical and pathological factors were recorded and related to the occurrence of postoperative complications/mortality, overall survival (OS), and progression-free survival. Results: Of 51 study patients, 17 (33%) had overweight (body mass index ≥ 25) at start of treatment and 20 patients (39%) were malnourished at hospital admission for surgery. Postoperative complications occurred in 25 patients (49%), 6 had major complications, and 2 died within 90 days after surgery, but no significant predictive factors were found. Overall, weight loss ≥5% during induction period was associated with shorter OS (p = 0.03), but especially overweight patients experiencing weight loss ≥5% during induction period (n = 7) had shorter OS (hazard ratio 4.63, p = 0.005; log-rank p = 0.04) and progression-free survival (hazard ratio 6.03, p = 0.007). Conclusions: This study indicates that malnutrition especially in overweight patients negatively influences survival outcomes of trimodality treatment for stage III NSCLC.

Original languageEnglish
Pages (from-to)1563-1568
Number of pages6
JournalJournal of Thoracic Oncology
Volume6
Issue number9
DOIs
Publication statusPublished - Sept 2011
Externally publishedYes

Keywords

  • BMI
  • Concurrent chemoradiotherapy
  • NSCLC
  • Nutritional status
  • Surgery

Fingerprint

Dive into the research topics of 'Nutrition during trimodality treatment in stage III non-small cell lung cancer: Not only important for underweight patients'. Together they form a unique fingerprint.

Cite this