Oncofertility Perspectives for Girls with Cancer

M. E.Madeleine van der Perk, Anne Lotte L.F. van der Kooi, Annelies M.E. Bos, Simone L. Broer, Margreet A. Veening, Jeanette van Leeuwen, Hanneke M. van Santen, Wendy van Dorp, Marry M. van den Heuvel-Eibrink

Research output: Contribution to journalEditorial

3 Citations (Scopus)


Infertility is a serious early, as well as late, effect of childhood cancer treatment. If addressed in a timely manner at diagnosis, fertility preservation measures can be taken, preferably before the start of cancer treatment. However, pediatric oncologists might remain reluctant to offer counseling on fertility-preservation methods, although infrastructure to freeze ovarian tissue has become available and is currently considered standard care for pre- and postpubertal girls at high risk of gonadal damage. More importantly, risk factors have been identified for cancer treatment-related impairment of gonadal function, and the first successful pregnancies have been reported after autotransplanted ovarian tissue, which has been harvested from children. Additionally, great progress has been made in the field of ex vivo maturation of oocytes in frozen ovarian tissue, which provides opportunities for those at risk of ovarian micrometastasis. Hence, it is time to counsel girls at risk and make every effort to cryopreserve their ovarian tissue, now more than ever before.

Original languageEnglish
Pages (from-to)523-526
Number of pages4
JournalJournal of Pediatric and Adolescent Gynecology
Issue number5
Publication statusPublished - Oct 2022


  • Fertility preservation
  • Ovarian tissue cryopreservation
  • Ovarian tissue transplantation
  • Pediatric oncology
  • Pregnancy
  • Ovary
  • Neoplasms/therapy
  • Cryopreservation
  • Humans
  • Female
  • Oocytes
  • Fertility Preservation/methods


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