Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer

F van Leeuwen, R Nusse

Research output: Contribution to journalReview articlepeer-review

46 Citations (Scopus)


In this short review, we will give an overview of the various genes that can be activated by insertion of proviral DNA of the mouse mammary tumor virus during the formation of mammary cancer. These genes fall within three families: Wnt genes, FGF genes and Notch-related genes. We will summarize our current understanding of the roles of these genes in tumorigenesis and in normal development, and the mechanisms of action of their gene products. Finally, we will give some examples of cooperation between these genes in various biological settings.

Original languageEnglish
Pages (from-to)127-33
Number of pages7
JournalSeminars in cancer biology
Issue number3
Publication statusPublished - Jun 1995
Externally publishedYes


  • Animals
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Regulation, Viral
  • Mammary Neoplasms, Experimental/genetics
  • Mammary Tumor Virus, Mouse/genetics
  • Mice
  • Oncogenes
  • Retroviridae Infections/virology
  • Tumor Virus Infections/virology


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