Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Tomohiro Mizutani; Yoshiyuki Tsukamoto; Hans Clevers

doi:10.1083/jcb.201704014

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Tomohiro Mizutani
, Yoshiyuki Tsukamoto
, Hans Clevers

Research output: Contribution to journal › Comment/debate

2 Citations (Scopus)

Abstract

Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https ://doi .org /10 .1083 /jcb .201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

Original language	English
Pages (from-to)	1505-1507
Number of pages	3
Journal	Journal of Cell Biology
Volume	216
Issue number	6
DOIs	https://doi.org/10.1083/jcb.201704014
Publication status	Published - 1 Jun 2017
Externally published	Yes

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title = "Oncogene-inducible organoids as a miniature platform to assess cancer characteristics",

abstract = "Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https ://doi .org /10 .1083 /jcb .201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.",

author = "Tomohiro Mizutani and Yoshiyuki Tsukamoto and Hans Clevers",

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AU - Mizutani, Tomohiro

AU - Tsukamoto, Yoshiyuki

AU - Clevers, Hans

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Y1 - 2017/6/1

N2 - Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https ://doi .org /10 .1083 /jcb .201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

AB - Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https ://doi .org /10 .1083 /jcb .201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

UR - https://www.scopus.com/pages/publications/85021783817

U2 - 10.1083/jcb.201704014

DO - 10.1083/jcb.201704014

M3 - Comment/debate

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SP - 1505

EP - 1507

JO - Journal of Cell Biology

JF - Journal of Cell Biology

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ER -

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Abstract

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