Osteosarcoma of the hands and feet: A distinct clinico-pathological subgroup

Jakob K. Anninga, Piero Picci, Marta Fiocco, Herman M.J.A. Kroon, Daniel Vanel, Marco Alberghini, Hans Gelderblom, Pancras C.W. Hogendoorn

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26 Citations (Scopus)


Osteosarcomas of hands or feet are rare, and seemingly these cases differ in presentation and behavior compared to those in usual locations. The clinico-pathological presentation of patients with osteosarcomas of the hand or foot was studied and compared with published cases. Forty osteosarcomas were identified among 4,221 cases, representing 0.95 % of all osteosarcomas. Thirty of these were well documented. Mean age at diagnosis was 43 years (hands) and 36 years (feet) and male-female ratio was 1.2:1 and 2.0:1, respectively. In the hand, 62 % of the osteosarcomas presented in the metacarpals and 23 % in the phalanges, and only two cases occurred in the carpal bones. Distribution in the foot was tarsal bones 56 %, metatarsal bones 33 %, and phalanges 11 %.Of the cases in the hand 54 % were of high grade and of those in the foot 71 %. Survival of osteosarcomas of the hand or foot was 81 %. Only patients with high-grade osteosarcoma died of the disease. Histological grade was the only significant variable related to survival. High-grade osteosarcoma of the hand or feet should be treated similar to those in conventional sites. Osteosarcomas of hands or feet are rare and in a relative high proportion are of low grade. Survival in high-grade cases is comparable to that in conventional sites.

Original languageEnglish
Pages (from-to)109-120
Number of pages12
JournalVirchows Archiv
Issue number1
Publication statusPublished - Jan 2013
Externally publishedYes


  • Bone neoplasm
  • Bone tumor
  • Feet
  • Hands
  • Osteogenic sarcoma
  • Osteosarcoma
  • Sarcoma


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