Outcome of pediatric acute myeloid leukemia (AML) in low- and middle-income countries: a systematic review of the literature

Romy E. Van Weelderen, Kim Klein, Meyrina D. Natawidjaja, Ralph De Vries, Gertjan J.L. Kaspers

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Introduction: Survival rates of pediatric acute myeloid leukemia (AML) in low- and middle-income countries (LMICs) seem extremely poor, and the available literature on the matter is scarce. Accordingly, there is a limited understanding of poor treatment outcomes seen in this population. Areas covered: We provide an overview of the available literature with respect to treatment outcomes of pediatric AML in LMICs yielding poor outcomes compared to high-income countries. Moreover, treatment outcomes vary markedly between LMICs. In addition, there is a wide variation among studies in how treatment outcomes are reported and analyzed. Expert opinion: The substantially inferior treatment outcomes of pediatric AML in LMICs emphasize the unprecedented importance of global initiatives and international collaborations to improve the survival of these patients. A coordinated approach is necessary to carry out country-specific situational analyses. These analyses will result in operational plans on how to structurally implement childhood cancer registries, align healthcare infrastructure, build on capacities, and provide universal health coverage in LMICs. In addition, we strongly recommend that, in the future, LMICs document, analyze, and publish pediatric AML treatment outcomes in a more structured and uniform manner.

Original languageEnglish
Pages (from-to)765-780
Number of pages16
JournalExpert Review of Anticancer Therapy
Volume21
Issue number7
DOIs
Publication statusPublished - 2021

Keywords

  • childhood cancer
  • developing countries
  • low- and middle-income countries
  • pediatric acute myeloid leukemia
  • survival

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