Past, current and future protocols for combined modality therapy in childhood medulloblastoma

Patricia Kaaijk, Antoinette Y.N. Schouten-van Meeteren, Ben J. Slotman, Gertjan J.L. Kaspers

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Radiotherapy plays a major role in the management of brain tumors, together with surgical resection and more recently, chemotherapy. Improved efficacy of radiotherapy, ranging from novel techniques of radiotherapy to combination with (new) chemotherapeutic drugs or agents that selectively target tumor cells, are currently being explored and offer some hope for improvement of the prognosis of primary brain tumors. This approach might also enable reducing radiation doses, thereby potentially decreasing the risk of severe late effects in pediatric brain tumor patients. This review will evaluate past, current and future treatment approaches of combined modality therapy in childhood medulloblastoma.

Original languageEnglish
Pages (from-to)79-90
Number of pages12
JournalExpert Review of Anticancer Therapy
Issue number1
Publication statusPublished - Feb 2003
Externally publishedYes


  • Antisense technology
  • Brain tumor
  • Carboplatin
  • CCNU
  • Chemotherapy
  • Childhood
  • Cisplatin
  • COX-2
  • Cyclophosphamide
  • Cytarabine
  • Eroposide
  • Farnesyltransferase inhibitors
  • High-dose chemotherapy
  • Hydroxyurea
  • Hypoxia
  • Ifosfamide
  • Inhibitors
  • Medulloblastoma
  • Methotrexate
  • Methylprednisone
  • Nitrogen mustard
  • Prednisone
  • Procarbazine
  • Proto-oncogene
  • Radiosensitization
  • Radiotherapy
  • Reduced craniospinal radiation dose
  • Targeted therapy
  • Tyrosine kinase inhibitors
  • Vincristine


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