Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis

Heleen D. Jüngen; Talya L. Dayton

doi:10.1016/j.devcel.2026.05.006

Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis

Heleen D. Jüngen
, Talya L. Dayton

Research output: Contribution to journal › Comment/debate

Abstract

Appendiceal adenocarcinoma (AC) frequently metastasizes to the peritoneum, yet the mechanisms underlying this transition remain poorly understood. In this issue of Developmental Cell , Mahmoud et al. ¹ establish a patient-derived tumor organoid (PDTO) biobank and xenograft model that recapitulate AC progression, reveal shifts in cellular states, and identify potential therapeutic targets.

Original language	English
Pages (from-to)	1165-1166
Number of pages	2
Journal	Developmental Cell
Volume	61
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2026.05.006
Publication status	Published - 10 Jun 2026
Externally published	Yes

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10.1016/j.devcel.2026.05.006

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@article{87e6261539a84e9c81553f7d796d33c1,

title = "Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis",

abstract = "Appendiceal adenocarcinoma (AC) frequently metastasizes to the peritoneum, yet the mechanisms underlying this transition remain poorly understood. In this issue of Developmental Cell , Mahmoud et al. 1 establish a patient-derived tumor organoid (PDTO) biobank and xenograft model that recapitulate AC progression, reveal shifts in cellular states, and identify potential therapeutic targets.",

author = "J{\"u}ngen, \{Heleen D.\} and Dayton, \{Talya L.\}",

note = "Publisher Copyright: {\textcopyright} 2026 Elsevier Inc.",

year = "2026",

month = jun,

day = "10",

doi = "10.1016/j.devcel.2026.05.006",

language = "English",

volume = "61",

pages = "1165--1166",

journal = "Developmental Cell",

issn = "1534-5807",

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number = "6",

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TY - JOUR

T1 - Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis

AU - Jüngen, Heleen D.

AU - Dayton, Talya L.

PY - 2026/6/10

Y1 - 2026/6/10

N2 - Appendiceal adenocarcinoma (AC) frequently metastasizes to the peritoneum, yet the mechanisms underlying this transition remain poorly understood. In this issue of Developmental Cell , Mahmoud et al. 1 establish a patient-derived tumor organoid (PDTO) biobank and xenograft model that recapitulate AC progression, reveal shifts in cellular states, and identify potential therapeutic targets.

AB - Appendiceal adenocarcinoma (AC) frequently metastasizes to the peritoneum, yet the mechanisms underlying this transition remain poorly understood. In this issue of Developmental Cell , Mahmoud et al. 1 establish a patient-derived tumor organoid (PDTO) biobank and xenograft model that recapitulate AC progression, reveal shifts in cellular states, and identify potential therapeutic targets.

UR - https://www.scopus.com/pages/publications/105040907329

U2 - 10.1016/j.devcel.2026.05.006

DO - 10.1016/j.devcel.2026.05.006

M3 - Comment/debate

AN - SCOPUS:105040907329

SN - 1534-5807

VL - 61

SP - 1165

EP - 1166

JO - Developmental Cell

JF - Developmental Cell

IS - 6

ER -

Patient-derived models uncover developmental state shifts in appendiceal cancer metastasis

Abstract

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