Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Ye Yao; Xiaoya Xu; Lifeng Yang; Ji Zhu; Juefeng Wan; Lijun Shen; Fan Xia; Guoxiang Fu; Yun Deng; Mengxue Pan; Qiang Guo; Xiaoxue Gao; Yuanchuang Li; Xinxin Rao; Yi Zhou; Liping Liang; Yaqi Wang; Jing Zhang; Hui Zhang; Guichao Li; Lixing Zhang; Junjie Peng; Sanjun Cai; Chen Hu; Jianjun Gao; Hans Clevers; Zhen Zhang; Guoqiang Hua

doi:10.1016/j.stem.2019.10.010

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Ye Yao
, Xiaoya Xu
, Lifeng Yang
, Ji Zhu
, Juefeng Wan
, Lijun Shen
, Fan Xia
, Guoxiang Fu
, Yun Deng
, Mengxue Pan
, Qiang Guo
, Xiaoxue Gao
, Yuanchuang Li
, Xinxin Rao
, Yi Zhou
, Liping Liang
, Yaqi Wang
, Jing Zhang
, Hui Zhang
, Guichao Li

Lixing Zhang, Junjie Peng, Sanjun Cai, Chen Hu, Jianjun Gao, Hans Clevers, Zhen Zhang, Guoqiang Hua

Research output: Contribution to journal › Article › peer-review

616 Citations (Scopus)

Abstract

Yao et al. generated a patient-derived organoid (PDO) biobank from patients with locally advanced rectal cancer (LARC) and reported that organoids had similar molecular profiles to those of the patient tumor and that PDOs can predict LARC patient chemoradiation responses, reinforcing their value as a companion diagnostic tool in LARC treatment.

Original language	English
Pages (from-to)	17-26.e6
Journal	Cell stem cell
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2019.10.010
Publication status	Published - 2 Jan 2020
Externally published	Yes

Keywords

chemoradiation
clinical response
organoids
predict
rectal cancer

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10.1016/j.stem.2019.10.010

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title = "Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer",

abstract = "Yao et al. generated a patient-derived organoid (PDO) biobank from patients with locally advanced rectal cancer (LARC) and reported that organoids had similar molecular profiles to those of the patient tumor and that PDOs can predict LARC patient chemoradiation responses, reinforcing their value as a companion diagnostic tool in LARC treatment.",

keywords = "chemoradiation, clinical response, organoids, predict, rectal cancer",

author = "Ye Yao and Xiaoya Xu and Lifeng Yang and Ji Zhu and Juefeng Wan and Lijun Shen and Fan Xia and Guoxiang Fu and Yun Deng and Mengxue Pan and Qiang Guo and Xiaoxue Gao and Yuanchuang Li and Xinxin Rao and Yi Zhou and Liping Liang and Yaqi Wang and Jing Zhang and Hui Zhang and Guichao Li and Lixing Zhang and Junjie Peng and Sanjun Cai and Chen Hu and Jianjun Gao and Hans Clevers and Zhen Zhang and Guoqiang Hua",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = jan,

day = "2",

doi = "10.1016/j.stem.2019.10.010",

language = "English",

volume = "26",

pages = "17--26.e6",

journal = "Cell stem cell",

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}

Yao, Y, Xu, X, Yang, L, Zhu, J, Wan, J, Shen, L, Xia, F, Fu, G, Deng, Y, Pan, M, Guo, Q, Gao, X, Li, Y, Rao, X, Zhou, Y, Liang, L, Wang, Y, Zhang, J, Zhang, H, Li, G, Zhang, L, Peng, J, Cai, S, Hu, C, Gao, J, Clevers, H, Zhang, Z & Hua, G 2020, 'Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer', Cell stem cell, vol. 26, no. 1, pp. 17-26.e6. https://doi.org/10.1016/j.stem.2019.10.010

TY - JOUR

T1 - Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

AU - Yao, Ye

AU - Xu, Xiaoya

AU - Yang, Lifeng

AU - Zhu, Ji

AU - Wan, Juefeng

AU - Shen, Lijun

AU - Xia, Fan

AU - Fu, Guoxiang

AU - Deng, Yun

AU - Pan, Mengxue

AU - Guo, Qiang

AU - Gao, Xiaoxue

AU - Li, Yuanchuang

AU - Rao, Xinxin

AU - Zhou, Yi

AU - Liang, Liping

AU - Wang, Yaqi

AU - Zhang, Jing

AU - Zhang, Hui

AU - Li, Guichao

AU - Zhang, Lixing

AU - Peng, Junjie

AU - Cai, Sanjun

AU - Hu, Chen

AU - Gao, Jianjun

AU - Clevers, Hans

AU - Zhang, Zhen

AU - Hua, Guoqiang

PY - 2020/1/2

Y1 - 2020/1/2

N2 - Yao et al. generated a patient-derived organoid (PDO) biobank from patients with locally advanced rectal cancer (LARC) and reported that organoids had similar molecular profiles to those of the patient tumor and that PDOs can predict LARC patient chemoradiation responses, reinforcing their value as a companion diagnostic tool in LARC treatment.

AB - Yao et al. generated a patient-derived organoid (PDO) biobank from patients with locally advanced rectal cancer (LARC) and reported that organoids had similar molecular profiles to those of the patient tumor and that PDOs can predict LARC patient chemoradiation responses, reinforcing their value as a companion diagnostic tool in LARC treatment.

KW - chemoradiation

KW - clinical response

KW - organoids

KW - predict

KW - rectal cancer

UR - https://www.scopus.com/pages/publications/85076911783

U2 - 10.1016/j.stem.2019.10.010

DO - 10.1016/j.stem.2019.10.010

M3 - Article

C2 - 31761724

AN - SCOPUS:85076911783

SN - 1934-5909

VL - 26

SP - 17-26.e6

JO - Cell stem cell

JF - Cell stem cell

IS - 1

ER -

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Abstract

Keywords

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