Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept

J Wolter Oosterhuis; Suzanne H P Peeters; Vincent T H B M Smit; Hans Stoop; Leendert H J Looijenga; Henk W Elzevier; Suzanne Osanto

doi:10.1387/ijdb.130141jo

Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept

J Wolter Oosterhuis
, Suzanne H P Peeters
, Vincent T H B M Smit
, Hans Stoop
, Leendert H J Looijenga
, Henk W Elzevier
, Suzanne Osanto

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization.

Original language	English
Pages (from-to)	153-7
Number of pages	5
Journal	The International journal of developmental biology
Volume	57
Issue number	2-4
DOIs	https://doi.org/10.1387/ijdb.130141jo
Publication status	Published - 2013
Externally published	Yes

Keywords

Adenocarcinoma/diagnosis
Adult
Cell- and Tissue-Based Therapy
Humans
Intestines/pathology
Leiomyosarcoma/diagnosis
Male
Neoplasm Recurrence, Local/diagnosis
Neoplasms, Germ Cell and Embryonal/complications
Neoplastic Stem Cells/pathology
Prognosis
Testicular Neoplasms/complications

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10.1387/ijdb.130141jo

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Oosterhuis, J. W., Peeters, S. H. P., Smit, V. T. H. B. M., Stoop, H., Looijenga, L. H. J., Elzevier, H. W., & Osanto, S. (2013). Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept. The International journal of developmental biology, 57(2-4), 153-7. https://doi.org/10.1387/ijdb.130141jo

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title = "Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept",

abstract = "Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization.",

keywords = "Adenocarcinoma/diagnosis, Adult, Cell- and Tissue-Based Therapy, Humans, Intestines/pathology, Leiomyosarcoma/diagnosis, Male, Neoplasm Recurrence, Local/diagnosis, Neoplasms, Germ Cell and Embryonal/complications, Neoplastic Stem Cells/pathology, Prognosis, Testicular Neoplasms/complications",

author = "Oosterhuis, \{J Wolter\} and Peeters, \{Suzanne H P\} and Smit, \{Vincent T H B M\} and Hans Stoop and Looijenga, \{Leendert H J\} and Elzevier, \{Henk W\} and Suzanne Osanto",

year = "2013",

doi = "10.1387/ijdb.130141jo",

language = "English",

volume = "57",

pages = "153--7",

journal = "The International journal of developmental biology",

issn = "0214-6282",

publisher = "UPV/EHU Press",

number = "2-4",

}

Oosterhuis, JW, Peeters, SHP, Smit, VTHBM, Stoop, H, Looijenga, LHJ, Elzevier, HW & Osanto, S 2013, 'Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept', The International journal of developmental biology, vol. 57, no. 2-4, pp. 153-7. https://doi.org/10.1387/ijdb.130141jo

Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept. / Oosterhuis, J Wolter; Peeters, Suzanne H P; Smit, Vincent T H B M et al.
In: The International journal of developmental biology, Vol. 57, No. 2-4, 2013, p. 153-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma

T2 - illustration of potential and flaw of the cancer stem cell therapy concept

AU - Oosterhuis, J Wolter

AU - Peeters, Suzanne H P

AU - Smit, Vincent T H B M

AU - Stoop, Hans

AU - Looijenga, Leendert H J

AU - Elzevier, Henk W

AU - Osanto, Suzanne

PY - 2013

Y1 - 2013

N2 - Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization.

AB - Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization.

KW - Adenocarcinoma/diagnosis

KW - Adult

KW - Cell- and Tissue-Based Therapy

KW - Humans

KW - Intestines/pathology

KW - Leiomyosarcoma/diagnosis

KW - Male

KW - Neoplasm Recurrence, Local/diagnosis

KW - Neoplasms, Germ Cell and Embryonal/complications

KW - Neoplastic Stem Cells/pathology

KW - Prognosis

KW - Testicular Neoplasms/complications

UR - https://www.scopus.com/pages/publications/84880056383

U2 - 10.1387/ijdb.130141jo

DO - 10.1387/ijdb.130141jo

M3 - Article

C2 - 23784825

SN - 0214-6282

VL - 57

SP - 153

EP - 157

JO - The International journal of developmental biology

JF - The International journal of developmental biology

IS - 2-4

ER -

Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept

Abstract

Keywords

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