PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

Laure Hirsch; Laurence Zitvogel; Alexander Eggermont; Aurelien Marabelle

doi:10.1038/s41416-018-0294-4

PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

Laure Hirsch
, Laurence Zitvogel
, Alexander Eggermont
, Aurelien Marabelle

Research output: Contribution to journal › Editorial

104 Citations (Scopus)

Abstract

Clinical trials have now identified over 30 cancer histotypes with sensitivity to anti-PD-(L)1 therapies. It is the first time in oncology that a class of drugs has demonstrated such a wide spectrum of activity in monotherapy. This subgroup of cancers (‘PD-Lomas’) is driving the clinical research strategies for the next generation of combination immunotherapy.

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	British journal of cancer
Volume	120
Issue number	1
DOIs	https://doi.org/10.1038/s41416-018-0294-4
Publication status	Published - 8 Jan 2019
Externally published	Yes

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10.1038/s41416-018-0294-4

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title = "PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade",

abstract = "Clinical trials have now identified over 30 cancer histotypes with sensitivity to anti-PD-(L)1 therapies. It is the first time in oncology that a class of drugs has demonstrated such a wide spectrum of activity in monotherapy. This subgroup of cancers ({\textquoteleft}PD-Lomas{\textquoteright}) is driving the clinical research strategies for the next generation of combination immunotherapy.",

author = "Laure Hirsch and Laurence Zitvogel and Alexander Eggermont and Aurelien Marabelle",

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T2 - a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

AU - Hirsch, Laure

AU - Zitvogel, Laurence

AU - Eggermont, Alexander

AU - Marabelle, Aurelien

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Clinical trials have now identified over 30 cancer histotypes with sensitivity to anti-PD-(L)1 therapies. It is the first time in oncology that a class of drugs has demonstrated such a wide spectrum of activity in monotherapy. This subgroup of cancers (‘PD-Lomas’) is driving the clinical research strategies for the next generation of combination immunotherapy.

AB - Clinical trials have now identified over 30 cancer histotypes with sensitivity to anti-PD-(L)1 therapies. It is the first time in oncology that a class of drugs has demonstrated such a wide spectrum of activity in monotherapy. This subgroup of cancers (‘PD-Lomas’) is driving the clinical research strategies for the next generation of combination immunotherapy.

UR - https://www.scopus.com/pages/publications/85056303637

U2 - 10.1038/s41416-018-0294-4

DO - 10.1038/s41416-018-0294-4

M3 - Editorial

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AN - SCOPUS:85056303637

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IS - 1

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PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

Abstract

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