TY - JOUR
T1 - Pediatric renal tumor epidemiology
T2 - Global perspectives, progress, and challenges
AU - Libes, Jaime
AU - Hol, Janna
AU - Neto, Joaquim Caetano de Aguirre
AU - Vallance, Kelly L.
AU - Tinteren, Harm van
AU - Benedetti, Daniel J.
AU - Villar, Gema Lucia Ramirez
AU - Duncan, Catriona
AU - Ehrlich, Peter F.
N1 - © 2022 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.
PY - 2023/1
Y1 - 2023/1
N2 - Pediatric renal tumors account for 3%–11% of childhood cancers, the most common of which is Wilms tumor or nephroblastoma. Epidemiology plays a key role in cancer prevention and control by describing the distribution of cancer and discovering risk factors for cancer. Large pediatric research consortium trials have led to a clearer understanding of pediatric renal tumors, identification of risk factors, and development of more risk-adapted therapies. These therapies have improved event-free and overall survival for children. However, several challenges remain and not all children have benefited from the improved outcomes. In this article, we review the global epidemiology of pediatric renal tumors, including key consortium and global studies. We identify current knowledge gaps and challenges facing both high and low middle-incomes countries.
AB - Pediatric renal tumors account for 3%–11% of childhood cancers, the most common of which is Wilms tumor or nephroblastoma. Epidemiology plays a key role in cancer prevention and control by describing the distribution of cancer and discovering risk factors for cancer. Large pediatric research consortium trials have led to a clearer understanding of pediatric renal tumors, identification of risk factors, and development of more risk-adapted therapies. These therapies have improved event-free and overall survival for children. However, several challenges remain and not all children have benefited from the improved outcomes. In this article, we review the global epidemiology of pediatric renal tumors, including key consortium and global studies. We identify current knowledge gaps and challenges facing both high and low middle-incomes countries.
KW - clear cell sarcoma of kidney
KW - epidemiology
KW - global
KW - pediatric renal cell carcinoma
KW - rhabdoid tumor
KW - Wilms tumor
UR - http://www.scopus.com/inward/record.url?scp=85141379468&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/03528010-d5f0-32a6-8cf2-39132bfd2f77/
U2 - 10.1002/pbc.30006
DO - 10.1002/pbc.30006
M3 - Review article
C2 - 36326750
AN - SCOPUS:85141379468
SN - 1545-5009
VL - 70
SP - e30006
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 1
M1 - e30006
ER -