Peripheral stem cell harvest using regular chemotherapy schedules in childhood cancer

Saskia L. Gooskens, Eric Braakman, Anne Loes Van Den Boom, Cynthia So-Osman, Ferdinand De Winter, Rob Pieters, Marry M. Van Den Heuvel-Eibrink

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Prediction of the best moment for the harvest of PBSCs after standard chemotherapy followed by filgrastim in children with cancer is difficult. We retrospectively analyzed the moment of harvesting of 152 procedures in 94 patients. The start of apheresis was guided by WBC count and CD34+ cell measurement in peripheral blood. We defined the first day of filgrastim administration, after completion of mobilizing chemotherapy, as day 1. Median time to harvest in different subgroups is as follows: neuroblastoma 11 days (range, 6-29 days), Ewing's sarcoma nine days (range, 7-15 days), brain tumor 10 days (range, 7-15 days), relapsed Wilms' tumor 16 days (range, 9-20 days), and extracranial GCT seven days (range, 6-14 days). Patients harvested after cyclophosphamide priming (time to harvest within a range of 8-9 days) were analyzed as a separate group. The optimal moment for harvesting in different types of tumors was highly variable, although most consistent in patients diagnosed with Ewing's sarcoma or brain tumors and after cyclophosphamide priming.

Original languageEnglish
Pages (from-to)758-765
Number of pages8
JournalPediatric Transplantation
Volume16
Issue number7
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

Keywords

  • cancer
  • children
  • peripheral blood stem cell harvest
  • stem cell mobilization
  • timing

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