TY - JOUR
T1 - Placental‐like alkaline phosphatase and DNA flow cytometry in spermatocytic seminoma
AU - Dekker, Inge
AU - Rozeboom, Thea
AU - Delemarre, Jan
AU - Dam, Anke
AU - Oosterhuis, Jan Wolter
PY - 1992/2/15
Y1 - 1992/2/15
N2 - Immunohistochemical analysis was done on 7 testicular tumors classified as spermatocytic seminoma (SS) and 25 classic seminomas. Except for a few scattered cells, the spermatocytic seminomas were negative for placental‐like alkaline phosphatase (PLAP); the classic seminomas were all positive for this enzyme. The SS also were negative for alpha‐fetoprotein (AFP), beta‐human chorionic gonadotropin (hCG), and leukocyte common antigen (LCA). The ploidy of the seven tumors of SS was as follows: two, diploid; two, near‐diploid; one, tetraploid; one, aneuploid; and one, uninterpretable. The essentially negative staining of SS for PLAP was strikingly different from the pattern in classic seminoma. Thus, staining for this enzyme is useful for making the differential diagnosis between classic seminoma and SS. To differentiate between malignant lymphoma and SS, staining for leukocyte common antigen is helpful. Cancer 1992; 69:993–996.
AB - Immunohistochemical analysis was done on 7 testicular tumors classified as spermatocytic seminoma (SS) and 25 classic seminomas. Except for a few scattered cells, the spermatocytic seminomas were negative for placental‐like alkaline phosphatase (PLAP); the classic seminomas were all positive for this enzyme. The SS also were negative for alpha‐fetoprotein (AFP), beta‐human chorionic gonadotropin (hCG), and leukocyte common antigen (LCA). The ploidy of the seven tumors of SS was as follows: two, diploid; two, near‐diploid; one, tetraploid; one, aneuploid; and one, uninterpretable. The essentially negative staining of SS for PLAP was strikingly different from the pattern in classic seminoma. Thus, staining for this enzyme is useful for making the differential diagnosis between classic seminoma and SS. To differentiate between malignant lymphoma and SS, staining for leukocyte common antigen is helpful. Cancer 1992; 69:993–996.
UR - http://www.scopus.com/inward/record.url?scp=0026543022&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19920215)69:4<993::AID-CNCR2820690427>3.0.CO;2-8
DO - 10.1002/1097-0142(19920215)69:4<993::AID-CNCR2820690427>3.0.CO;2-8
M3 - Article
C2 - 1310437
AN - SCOPUS:0026543022
SN - 0008-543X
VL - 69
SP - 993
EP - 996
JO - Cancer
JF - Cancer
IS - 4
ER -