Placing the Plasmodium falciparum epigenome on the map

Wieteke A.M. Hoeijmakers, Hendrik G. Stunnenberg, Richárd Bártfai

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

It is becoming increasingly evident that epigenetic mechanisms that act on and regulate chromatin structure play a key role in the development, adaptation, and survival of the malaria parasite within its human host. The study of epigenetics in Plasmodium falciparum started to flourish in recent years due to improvement of genomic technologies. Here we summarize the knowledge gained from genome-wide localization profiling of different epigenetic features, and discuss hypotheses emerging from the analysis of these 'descriptive' epigenetic maps. Furthermore, we highlight key questions to be answered, and provide a glimpse of developments required to gain true mechanistic understanding and to lift this maturing field to the next level.

Original languageEnglish
Pages (from-to)486-495
Number of pages10
JournalTrends in Parasitology
Volume28
Issue number11
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

Keywords

  • Chromatin
  • Epigenome
  • Histone modification
  • Histone variant
  • Malaria
  • Nucleosome
  • Plasmodium

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