Poised RNA Polymerase II Gives Pause for Thought

Thanasis Margaritis; Frank C.P. Holstege

doi:10.1016/j.cell.2008.04.027

Poised RNA Polymerase II Gives Pause for Thought

Thanasis Margaritis
, Frank C.P. Holstege

Research output: Contribution to journal › Short survey › peer-review

128 Citations (Scopus)

Abstract

Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

Original language	English
Pages (from-to)	581-584
Number of pages	4
Journal	Cell
Volume	133
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2008.04.027
Publication status	Published - 16 May 2008
Externally published	Yes

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title = "Poised RNA Polymerase II Gives Pause for Thought",

abstract = "Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.",

author = "Thanasis Margaritis and Holstege, \{Frank C.P.\}",

note = "Funding Information: We thank E. Birney, M. Timmers, and R. Medema for helpful comments. F.H. is supported by the Netherlands Organization for Scientific Research grants 80547080, 91106009, 05071057, and 81702015 and the Netherlands Bioinformatics Centre.",

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AU - Margaritis, Thanasis

AU - Holstege, Frank C.P.

N1 - Funding Information: We thank E. Birney, M. Timmers, and R. Medema for helpful comments. F.H. is supported by the Netherlands Organization for Scientific Research grants 80547080, 91106009, 05071057, and 81702015 and the Netherlands Bioinformatics Centre.

PY - 2008/5/16

Y1 - 2008/5/16

N2 - Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

AB - Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

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DO - 10.1016/j.cell.2008.04.027

M3 - Short survey

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SN - 0092-8674

VL - 133

SP - 581

EP - 584

JO - Cell

JF - Cell

IS - 4

ER -

Poised RNA Polymerase II Gives Pause for Thought

Abstract

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