Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis

Mirjam E. van de Velde; Sofia el Manouni el Hassani; Gert Jan L. Kaspers; Jorrit Broertjes; Marc A. Benninga; Nanne K.H. de Boer; Andries E. Budding; Tim G.J. de Meij

doi:10.1097/MPH.0000000000002210

Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis

Mirjam E. van de Velde, Sofia el Manouni el Hassani, Gert Jan L. Kaspers, Jorrit Broertjes, Marc A. Benninga, Nanne K.H. de Boer, Andries E. Budding, Tim G.J. de Meij

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Abstract

Introduction: Bloodstream infections (BSIs) cause treatment-related mortality in pediatric acute leukemia. We explored the potential of intestinal microbiota and fecal volatile organic compounds (VOCs) analyses to predict BSI. Methods: In this case-control study, fecal samples of pediatric acute leukemia patients were collected. Microbiota composition and fecal VOC profiles of BSI cases and matched non-BSI controls were compared. Results: In total, 6 patients were included, of which 1 developed BSI and 1 neutropenic fever. Both showed reduced microbial diversity and stability of Bacteroidetes. In the BSI case, Pantoea was identified 15 days before BSI. Significant differences in fecal VOC profiles were measured between the case and controls. Conclusion: Microbiota and fecal VOC could serve as biomarkers to predict BSI in pediatric leukemia.

Original language	English
Pages (from-to)	E152-E159
Journal	Journal of Pediatric Hematology/Oncology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1097/MPH.0000000000002210
Publication status	Published - 1 Jan 2022

Keywords

Chemotherapy
Diagnostics
Electronic nose
Invasive infection
Microbiota
Toxicity
Volatile organic compounds
Humans
Gastrointestinal Microbiome
Child, Preschool
Male
Sepsis/blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood
Pilot Projects
Adolescent
Female
Volatile Organic Compounds
Feces/chemistry
Child
Leukemia, Myeloid, Acute/blood

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10.1097/MPH.0000000000002210

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van de Velde, M. E., el Manouni el Hassani, S., Kaspers, G. J. L., Broertjes, J., Benninga, M. A., de Boer, N. K. H., Budding, A. E., & de Meij, T. G. J. (2022). Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis. Journal of Pediatric Hematology/Oncology, 44(1), E152-E159. https://doi.org/10.1097/MPH.0000000000002210

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title = "Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis",

abstract = "Introduction: Bloodstream infections (BSIs) cause treatment-related mortality in pediatric acute leukemia. We explored the potential of intestinal microbiota and fecal volatile organic compounds (VOCs) analyses to predict BSI. Methods: In this case-control study, fecal samples of pediatric acute leukemia patients were collected. Microbiota composition and fecal VOC profiles of BSI cases and matched non-BSI controls were compared. Results: In total, 6 patients were included, of which 1 developed BSI and 1 neutropenic fever. Both showed reduced microbial diversity and stability of Bacteroidetes. In the BSI case, Pantoea was identified 15 days before BSI. Significant differences in fecal VOC profiles were measured between the case and controls. Conclusion: Microbiota and fecal VOC could serve as biomarkers to predict BSI in pediatric leukemia.",

keywords = "Chemotherapy, Diagnostics, Electronic nose, Invasive infection, Microbiota, Toxicity, Volatile organic compounds, Humans, Gastrointestinal Microbiome, Child, Preschool, Male, Sepsis/blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood, Pilot Projects, Adolescent, Female, Volatile Organic Compounds, Feces/chemistry, Child, Leukemia, Myeloid, Acute/blood",

author = "{van de Velde}, {Mirjam E.} and {el Manouni el Hassani}, Sofia and Kaspers, {Gert Jan L.} and Jorrit Broertjes and Benninga, {Marc A.} and {de Boer}, {Nanne K.H.} and Budding, {Andries E.} and {de Meij}, {Tim G.J.}",

year = "2022",

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doi = "10.1097/MPH.0000000000002210",

language = "English",

volume = "44",

pages = "E152--E159",

journal = "Journal of Pediatric Hematology/Oncology",

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van de Velde, ME, el Manouni el Hassani, S, Kaspers, GJL, Broertjes, J, Benninga, MA, de Boer, NKH, Budding, AE & de Meij, TGJ 2022, 'Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis', Journal of Pediatric Hematology/Oncology, vol. 44, no. 1, pp. E152-E159. https://doi.org/10.1097/MPH.0000000000002210

TY - JOUR

T1 - Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis

AU - van de Velde, Mirjam E.

AU - el Manouni el Hassani, Sofia

AU - Kaspers, Gert Jan L.

AU - Broertjes, Jorrit

AU - Benninga, Marc A.

AU - de Boer, Nanne K.H.

AU - Budding, Andries E.

AU - de Meij, Tim G.J.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Introduction: Bloodstream infections (BSIs) cause treatment-related mortality in pediatric acute leukemia. We explored the potential of intestinal microbiota and fecal volatile organic compounds (VOCs) analyses to predict BSI. Methods: In this case-control study, fecal samples of pediatric acute leukemia patients were collected. Microbiota composition and fecal VOC profiles of BSI cases and matched non-BSI controls were compared. Results: In total, 6 patients were included, of which 1 developed BSI and 1 neutropenic fever. Both showed reduced microbial diversity and stability of Bacteroidetes. In the BSI case, Pantoea was identified 15 days before BSI. Significant differences in fecal VOC profiles were measured between the case and controls. Conclusion: Microbiota and fecal VOC could serve as biomarkers to predict BSI in pediatric leukemia.

AB - Introduction: Bloodstream infections (BSIs) cause treatment-related mortality in pediatric acute leukemia. We explored the potential of intestinal microbiota and fecal volatile organic compounds (VOCs) analyses to predict BSI. Methods: In this case-control study, fecal samples of pediatric acute leukemia patients were collected. Microbiota composition and fecal VOC profiles of BSI cases and matched non-BSI controls were compared. Results: In total, 6 patients were included, of which 1 developed BSI and 1 neutropenic fever. Both showed reduced microbial diversity and stability of Bacteroidetes. In the BSI case, Pantoea was identified 15 days before BSI. Significant differences in fecal VOC profiles were measured between the case and controls. Conclusion: Microbiota and fecal VOC could serve as biomarkers to predict BSI in pediatric leukemia.

KW - Chemotherapy

KW - Diagnostics

KW - Electronic nose

KW - Invasive infection

KW - Microbiota

KW - Toxicity

KW - Volatile organic compounds

KW - Humans

KW - Gastrointestinal Microbiome

KW - Child, Preschool

KW - Male

KW - Sepsis/blood

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood

KW - Pilot Projects

KW - Adolescent

KW - Female

KW - Volatile Organic Compounds

KW - Feces/chemistry

KW - Child

KW - Leukemia, Myeloid, Acute/blood

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DO - 10.1097/MPH.0000000000002210

M3 - Article

C2 - 34133377

AN - SCOPUS:85123325768

SN - 1077-4114

VL - 44

SP - E152-E159

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

IS - 1

ER -

Prediction of Bloodstream Infection in Pediatric Acute Leukemia by Microbiota and Volatile Organic Compounds Analysis

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Keywords

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