Prognostic significance and mechanism of Treg infiltration in human brain tumors

Joannes F.M. Jacobs; Albert J. Idema; Kalijn F. Bol; J. André Grotenhuis; I. Jolanda M. de Vries; Pieter Wesseling; Gosse J. Adema

doi:10.1016/j.jneuroim.2010.05.020

Prognostic significance and mechanism of Treg infiltration in human brain tumors

Joannes F.M. Jacobs, Albert J. Idema, Kalijn F. Bol, J. André Grotenhuis, I. Jolanda M. de Vries, Pieter Wesseling, Gosse J. Adema

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183 Citations (Scopus)

Abstract

Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune responses observed in these tumors. We reported that the percentage of tumor infiltrating Tregs is strongly correlated with the WHO grade of the brain tumor. We now report on the clinical follow-up of this patient cohort (n= 83). Subgroup analyses in patients with glioblastomas (n= 29) showed a moderate, not significant, inverted association between Tregs and survival. We further show that Tregs in glioblastomas, in contrast to other tumor infiltrating effector lymphocytes, highly express the CCR4 chemokine receptor. Moreover, the CCR4 ligand CCL22 is secreted by glioblastomas and may explain the specific Treg accumulation seen in these tumors.

Original language	English
Pages (from-to)	195-199
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	225
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.05.020
Publication status	Published - Aug 2010
Externally published	Yes

Keywords

CCL22
CCR4
Glioblastoma
Human
Prognosis
Regulatory T cell

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10.1016/j.jneuroim.2010.05.020

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title = "Prognostic significance and mechanism of Treg infiltration in human brain tumors",

abstract = "Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune responses observed in these tumors. We reported that the percentage of tumor infiltrating Tregs is strongly correlated with the WHO grade of the brain tumor. We now report on the clinical follow-up of this patient cohort (n= 83). Subgroup analyses in patients with glioblastomas (n= 29) showed a moderate, not significant, inverted association between Tregs and survival. We further show that Tregs in glioblastomas, in contrast to other tumor infiltrating effector lymphocytes, highly express the CCR4 chemokine receptor. Moreover, the CCR4 ligand CCL22 is secreted by glioblastomas and may explain the specific Treg accumulation seen in these tumors.",

keywords = "CCL22, CCR4, Glioblastoma, Human, Prognosis, Regulatory T cell",

author = "Jacobs, {Joannes F.M.} and Idema, {Albert J.} and Bol, {Kalijn F.} and Grotenhuis, {J. Andr{\'e}} and {de Vries}, {I. Jolanda M.} and Pieter Wesseling and Adema, {Gosse J.}",

note = "Funding Information: The authors thank Michel Oldenordkamp for technical assistance with the chemokine analysis. This study is financially supported by the Dutch Cancer Society (grant# KUN2003-2893 ), the EU-project Cancerimmunotherapy ( LSHC-CT-2006-518234 ) and the EU-project DC-THERA ( LSHB-CT-2004-512074 ). ",

year = "2010",

month = aug,

doi = "10.1016/j.jneuroim.2010.05.020",

language = "English",

volume = "225",

pages = "195--199",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Prognostic significance and mechanism of Treg infiltration in human brain tumors

AU - Jacobs, Joannes F.M.

AU - Idema, Albert J.

AU - Bol, Kalijn F.

AU - Grotenhuis, J. André

AU - de Vries, I. Jolanda M.

AU - Wesseling, Pieter

AU - Adema, Gosse J.

N1 - Funding Information: The authors thank Michel Oldenordkamp for technical assistance with the chemokine analysis. This study is financially supported by the Dutch Cancer Society (grant# KUN2003-2893 ), the EU-project Cancerimmunotherapy ( LSHC-CT-2006-518234 ) and the EU-project DC-THERA ( LSHB-CT-2004-512074 ).

PY - 2010/8

Y1 - 2010/8

N2 - Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune responses observed in these tumors. We reported that the percentage of tumor infiltrating Tregs is strongly correlated with the WHO grade of the brain tumor. We now report on the clinical follow-up of this patient cohort (n= 83). Subgroup analyses in patients with glioblastomas (n= 29) showed a moderate, not significant, inverted association between Tregs and survival. We further show that Tregs in glioblastomas, in contrast to other tumor infiltrating effector lymphocytes, highly express the CCR4 chemokine receptor. Moreover, the CCR4 ligand CCL22 is secreted by glioblastomas and may explain the specific Treg accumulation seen in these tumors.

AB - Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune responses observed in these tumors. We reported that the percentage of tumor infiltrating Tregs is strongly correlated with the WHO grade of the brain tumor. We now report on the clinical follow-up of this patient cohort (n= 83). Subgroup analyses in patients with glioblastomas (n= 29) showed a moderate, not significant, inverted association between Tregs and survival. We further show that Tregs in glioblastomas, in contrast to other tumor infiltrating effector lymphocytes, highly express the CCR4 chemokine receptor. Moreover, the CCR4 ligand CCL22 is secreted by glioblastomas and may explain the specific Treg accumulation seen in these tumors.

KW - CCL22

KW - CCR4

KW - Glioblastoma

KW - Human

KW - Prognosis

KW - Regulatory T cell

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AN - SCOPUS:77955658133

SN - 0165-5728

VL - 225

SP - 195

EP - 199

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Prognostic significance and mechanism of Treg infiltration in human brain tumors

Abstract

Keywords

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