Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases

Laurien D.C. Hoefnagel; Cathy B. Moelans; S. L. Meijer; Henk Jan Van Slooten; Pieter Wesseling; Jelle Wesseling; Pieter J. Westenend; Joost Bart; Cornelis A. Seldenrijk; Iris D. Nagtegaal; Joost Oudejans; Paul Van Der Valk; Carla H. Van Gils; Elsken Van Der Wall; Paul J. Van Diest

doi:10.1002/cncr.27518

Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases

Laurien D.C. Hoefnagel
, Cathy B. Moelans
, S. L. Meijer
, Henk Jan Van Slooten
, Pieter Wesseling
, Jelle Wesseling
, Pieter J. Westenend
, Joost Bart
, Cornelis A. Seldenrijk
, Iris D. Nagtegaal
, Joost Oudejans
, Paul Van Der Valk
, Carla H. Van Gils
, Elsken Van Der Wall
, Paul J. Van Diest

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

BACKGROUND: Changes in the receptor profile of primary breast cancers to their metastases (receptor conversion) have been described for the estrogen receptor α (ERα) and progesterone receptor (PR). The purpose of this study was to evaluate the impact of receptor conversion for ERα and PR on survival in a large group of distant non-bone breast cancer metastases. METHODS: Receptor conversion was studied by immunohistochemistry in a group of 233 metastatic breast cancer patients. Kaplan-Meier overall survival curves were plotted, and differences between the curves were analyzed by log-rank analysis. The additional prognostic value of conversion to established prognosticators was studied by Cox regression. RESULTS: Overall survival of patients showing conversion from positive to negative ERα or PR, or from negative to positive ERα or PR, or remaining receptor negative was comparable, and significantly worse than patients remaining receptor positive. ERα or PR receptor conversion from positive in the primary breast tumor to negative in distant metastases has independent negative prognostic value. CONCLUSIONS: ERα or PR receptor conversion from positive in the primary breast cancer to negative in distant metastases has negative prognostic value.

Original language	English
Pages (from-to)	4929-4935
Number of pages	7
Journal	Cancer
Volume	118
Issue number	20
DOIs	https://doi.org/10.1002/cncr.27518
Publication status	Published - 15 Oct 2012
Externally published	Yes

Keywords

breast cancer
estrogen receptor α
metastases
progesterone receptor
prognostic value
receptor conversion

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10.1002/cncr.27518

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Hoefnagel, L. D. C., Moelans, C. B., Meijer, S. L., Van Slooten, H. J., Wesseling, P., Wesseling, J., Westenend, P. J., Bart, J., Seldenrijk, C. A., Nagtegaal, I. D., Oudejans, J., Van Der Valk, P., Van Gils, C. H., Van Der Wall, E., & Van Diest, P. J. (2012). Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases. Cancer, 118(20), 4929-4935. https://doi.org/10.1002/cncr.27518

@article{fa86e905ee424176803dc618f0fc337a,

title = "Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases",

abstract = "BACKGROUND: Changes in the receptor profile of primary breast cancers to their metastases (receptor conversion) have been described for the estrogen receptor α (ERα) and progesterone receptor (PR). The purpose of this study was to evaluate the impact of receptor conversion for ERα and PR on survival in a large group of distant non-bone breast cancer metastases. METHODS: Receptor conversion was studied by immunohistochemistry in a group of 233 metastatic breast cancer patients. Kaplan-Meier overall survival curves were plotted, and differences between the curves were analyzed by log-rank analysis. The additional prognostic value of conversion to established prognosticators was studied by Cox regression. RESULTS: Overall survival of patients showing conversion from positive to negative ERα or PR, or from negative to positive ERα or PR, or remaining receptor negative was comparable, and significantly worse than patients remaining receptor positive. ERα or PR receptor conversion from positive in the primary breast tumor to negative in distant metastases has independent negative prognostic value. CONCLUSIONS: ERα or PR receptor conversion from positive in the primary breast cancer to negative in distant metastases has negative prognostic value.",

keywords = "breast cancer, estrogen receptor α, metastases, progesterone receptor, prognostic value, receptor conversion",

author = "Hoefnagel, \{Laurien D.C.\} and Moelans, \{Cathy B.\} and Meijer, \{S. L.\} and \{Van Slooten\}, \{Henk Jan\} and Pieter Wesseling and Jelle Wesseling and Westenend, \{Pieter J.\} and Joost Bart and Seldenrijk, \{Cornelis A.\} and Nagtegaal, \{Iris D.\} and Joost Oudejans and \{Van Der Valk\}, Paul and \{Van Gils\}, \{Carla H.\} and \{Van Der Wall\}, Elsken and \{Van Diest\}, \{Paul J.\}",

year = "2012",

month = oct,

day = "15",

doi = "10.1002/cncr.27518",

language = "English",

volume = "118",

pages = "4929--4935",

journal = "Cancer",

issn = "0008-543X",

publisher = "John Wiley and Sons Inc.",

number = "20",

}

Hoefnagel, LDC, Moelans, CB, Meijer, SL, Van Slooten, HJ, Wesseling, P, Wesseling, J, Westenend, PJ, Bart, J, Seldenrijk, CA, Nagtegaal, ID, Oudejans, J, Van Der Valk, P, Van Gils, CH, Van Der Wall, E & Van Diest, PJ 2012, 'Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases', Cancer, vol. 118, no. 20, pp. 4929-4935. https://doi.org/10.1002/cncr.27518

TY - JOUR

T1 - Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases

AU - Hoefnagel, Laurien D.C.

AU - Moelans, Cathy B.

AU - Meijer, S. L.

AU - Van Slooten, Henk Jan

AU - Wesseling, Pieter

AU - Wesseling, Jelle

AU - Westenend, Pieter J.

AU - Bart, Joost

AU - Seldenrijk, Cornelis A.

AU - Nagtegaal, Iris D.

AU - Oudejans, Joost

AU - Van Der Valk, Paul

AU - Van Gils, Carla H.

AU - Van Der Wall, Elsken

AU - Van Diest, Paul J.

PY - 2012/10/15

Y1 - 2012/10/15

N2 - BACKGROUND: Changes in the receptor profile of primary breast cancers to their metastases (receptor conversion) have been described for the estrogen receptor α (ERα) and progesterone receptor (PR). The purpose of this study was to evaluate the impact of receptor conversion for ERα and PR on survival in a large group of distant non-bone breast cancer metastases. METHODS: Receptor conversion was studied by immunohistochemistry in a group of 233 metastatic breast cancer patients. Kaplan-Meier overall survival curves were plotted, and differences between the curves were analyzed by log-rank analysis. The additional prognostic value of conversion to established prognosticators was studied by Cox regression. RESULTS: Overall survival of patients showing conversion from positive to negative ERα or PR, or from negative to positive ERα or PR, or remaining receptor negative was comparable, and significantly worse than patients remaining receptor positive. ERα or PR receptor conversion from positive in the primary breast tumor to negative in distant metastases has independent negative prognostic value. CONCLUSIONS: ERα or PR receptor conversion from positive in the primary breast cancer to negative in distant metastases has negative prognostic value.

AB - BACKGROUND: Changes in the receptor profile of primary breast cancers to their metastases (receptor conversion) have been described for the estrogen receptor α (ERα) and progesterone receptor (PR). The purpose of this study was to evaluate the impact of receptor conversion for ERα and PR on survival in a large group of distant non-bone breast cancer metastases. METHODS: Receptor conversion was studied by immunohistochemistry in a group of 233 metastatic breast cancer patients. Kaplan-Meier overall survival curves were plotted, and differences between the curves were analyzed by log-rank analysis. The additional prognostic value of conversion to established prognosticators was studied by Cox regression. RESULTS: Overall survival of patients showing conversion from positive to negative ERα or PR, or from negative to positive ERα or PR, or remaining receptor negative was comparable, and significantly worse than patients remaining receptor positive. ERα or PR receptor conversion from positive in the primary breast tumor to negative in distant metastases has independent negative prognostic value. CONCLUSIONS: ERα or PR receptor conversion from positive in the primary breast cancer to negative in distant metastases has negative prognostic value.

KW - breast cancer

KW - estrogen receptor α

KW - metastases

KW - progesterone receptor

KW - prognostic value

KW - receptor conversion

UR - https://www.scopus.com/pages/publications/84867332570

U2 - 10.1002/cncr.27518

DO - 10.1002/cncr.27518

M3 - Article

C2 - 22415862

AN - SCOPUS:84867332570

SN - 0008-543X

VL - 118

SP - 4929

EP - 4935

JO - Cancer

JF - Cancer

IS - 20

ER -

Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases

Abstract

Keywords

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