Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature

S. A.G. Kemink; P. Wesseling; G. F.F.M. Pieters; A. A.J. Verhofstad; A. R.M.M. Hermus; A. G.H. Smals

doi:10.1007/BF03345482

Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature

S. A.G. Kemink
, P. Wesseling
, G. F.F.M. Pieters
, A. A.J. Verhofstad
, A. R.M.M. Hermus
, A. G.H. Smals

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.

Original language	English
Pages (from-to)	70-75
Number of pages	6
Journal	Journal of Endocrinological Investigation
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/BF03345482
Publication status	Published - 1999
Externally published	Yes

Keywords

Carcinoma
Cushing
Histology
Metastasis
Pituitary

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10.1007/BF03345482

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abstract = "A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.",

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AU - Kemink, S. A.G.

AU - Wesseling, P.

AU - Pieters, G. F.F.M.

AU - Verhofstad, A. A.J.

AU - Hermus, A. R.M.M.

AU - Smals, A. G.H.

PY - 1999

Y1 - 1999

N2 - A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.

AB - A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.

KW - Carcinoma

KW - Cushing

KW - Histology

KW - Metastasis

KW - Pituitary

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AN - SCOPUS:0032969048

SN - 0391-4097

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JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

IS - 1

ER -

Progression of a Nelson's adenoma to pituitary carcinoma - A case report and review of the literature

Abstract

Keywords

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