Pump speed optimization in stable patients with a left ventricular assist device

Lotte E. Couperus, Victoria Delgado, Mand J.H. Khidir, Marijke P.M. Vester, Meindert Palmen, Marta Fiocco, Eduard R. Holman, Laurens F. Tops, Robert J.M. Klautz, Harriëtte F. Verwey, Martin J. Schalij, Saskia L.M.A. Beeres

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients, Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored, Hemodynamically stable patients (N = 17, age 61 [interquartile range {IQR} 51-66] years; 13 [77%] male) underwent a routine speed ramp test, Echocardiographic images were obtained at incremental speed settings to determine optimal pump speed, In 8 patients (47%), LVAD speed could be optimized, In these patients, RV fractional area change (26% [IQR 23-31] to 35% [IQR 27-45], p = 0.04) and RV longitudinal peak systolic strain (-13% [IQR -16 to -9] to -17% [IQR -18 to -11], p = 0.02) at 3 months follow-up improved without RV dilatation, Furthermore, N-terminal pro-brain natriuretic peptide level decreased (3,162 [IQR 1,336-4,487] ng/L to 2,294 [IQR 1,157-3,810] ng/L, p = 0.02),

Original languageEnglish
Pages (from-to)266-272
Number of pages7
JournalASAIO Journal
Issue number3
Publication statusPublished - 1 Jun 2017
Externally publishedYes


  • Left ventricular assist device
  • Pump speed
  • Right ventricular function


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