Randomized Trials in Melanoma: An Update

Alexander M.M. Eggermont

doi:10.1016/j.soc.2005.12.001

Randomized Trials in Melanoma: An Update

Alexander M.M. Eggermont

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

Abstract

No effective therapy for metastatic melanoma exists. Polychemotherapy or chemoimmunotherapy have not shown survival benefits. Vaccines have shown little activity in stage IV disease. To advance the identification of effective agents, new drugs can and should be offered as first-line treatment. Efforts must be made to improve understanding of the biology of malignant melanoma. Too many phase III trials have been conducted with a poor understanding of the mechanism of action of the involved drugs.

Original language	English
Pages (from-to)	439-451
Number of pages	13
Journal	Surgical Oncology Clinics of North America
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/j.soc.2005.12.001
Publication status	Published - Apr 2006
Externally published	Yes

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10.1016/j.soc.2005.12.001

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title = "Randomized Trials in Melanoma: An Update",

abstract = "No effective therapy for metastatic melanoma exists. Polychemotherapy or chemoimmunotherapy have not shown survival benefits. Vaccines have shown little activity in stage IV disease. To advance the identification of effective agents, new drugs can and should be offered as first-line treatment. Efforts must be made to improve understanding of the biology of malignant melanoma. Too many phase III trials have been conducted with a poor understanding of the mechanism of action of the involved drugs.",

author = "Eggermont, \{Alexander M.M.\}",

year = "2006",

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T2 - An Update

AU - Eggermont, Alexander M.M.

PY - 2006/4

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N2 - No effective therapy for metastatic melanoma exists. Polychemotherapy or chemoimmunotherapy have not shown survival benefits. Vaccines have shown little activity in stage IV disease. To advance the identification of effective agents, new drugs can and should be offered as first-line treatment. Efforts must be made to improve understanding of the biology of malignant melanoma. Too many phase III trials have been conducted with a poor understanding of the mechanism of action of the involved drugs.

AB - No effective therapy for metastatic melanoma exists. Polychemotherapy or chemoimmunotherapy have not shown survival benefits. Vaccines have shown little activity in stage IV disease. To advance the identification of effective agents, new drugs can and should be offered as first-line treatment. Efforts must be made to improve understanding of the biology of malignant melanoma. Too many phase III trials have been conducted with a poor understanding of the mechanism of action of the involved drugs.

UR - https://www.scopus.com/pages/publications/33745590474

U2 - 10.1016/j.soc.2005.12.001

DO - 10.1016/j.soc.2005.12.001

M3 - Review article

C2 - 16632225

AN - SCOPUS:33745590474

SN - 1055-3207

VL - 15

SP - 439

EP - 451

JO - Surgical Oncology Clinics of North America

JF - Surgical Oncology Clinics of North America

IS - 2

ER -

Randomized Trials in Melanoma: An Update

Abstract

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