TY - JOUR
T1 - Rare central nervous system tumors in adults
T2 - a population-based study of ependymomas, pilocytic astrocytomas, medulloblastomas, and intracranial germ cell tumors
AU - on behalf of the Dutch Neuro-Oncology Society (LWNO)
AU - Ho, Vincent K.Y.
AU - Gijtenbeek, Anja J.M.M.
AU - Wagemakers, Michiel
AU - Taal, Walter
AU - Van Linde, Myra E.
AU - Swaak-Kragten, Annemarie T.
AU - Kurt, Erkan
AU - Van Der Weide, Hiske L.
AU - Wesseling, Pieter
AU - De Vos, Filip Y.
AU - Bromberg, Jacoline E.C.
N1 - © The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Background: Ependymomas, pilocytic astrocytomas, medulloblastomas, and intracranial germ cell tumors occur relative frequently in children, but are rare central nervous system (CNS) tumors in adults. In this population-based survey, we established incidence, treatment, and survival patterns for these tumors diagnosed in adult patients (≥18 years) over a 30-year period (1989-2018). Methods: Data on 1384 ependymomas, 454 pilocytic astrocytomas, 205 medulloblastomas, and 112 intracranial germ cell tumors were obtained from the Netherlands Cancer Registry (NCR) on the basis of a histopathological diagnosis. For each tumor type, age-standardized incidence rates and estimated annual percentage change were calculated. Trends in incidence and main treatment modalities were reported per 5-year periods. Overall survival was calculated using the Kaplan-Meier method, and relative survival rates were estimated using the Pohar-Perme estimator. Results: Incidence and survival rates remained generally stable for pilocytic astrocytomas, medulloblastomas, and germ cell tumors. Increasing incidence was observed for spinal ependymomas, mostly for myxopapillary ependymomas, and survival improved over time for grade II ependymomas (P
AB - Background: Ependymomas, pilocytic astrocytomas, medulloblastomas, and intracranial germ cell tumors occur relative frequently in children, but are rare central nervous system (CNS) tumors in adults. In this population-based survey, we established incidence, treatment, and survival patterns for these tumors diagnosed in adult patients (≥18 years) over a 30-year period (1989-2018). Methods: Data on 1384 ependymomas, 454 pilocytic astrocytomas, 205 medulloblastomas, and 112 intracranial germ cell tumors were obtained from the Netherlands Cancer Registry (NCR) on the basis of a histopathological diagnosis. For each tumor type, age-standardized incidence rates and estimated annual percentage change were calculated. Trends in incidence and main treatment modalities were reported per 5-year periods. Overall survival was calculated using the Kaplan-Meier method, and relative survival rates were estimated using the Pohar-Perme estimator. Results: Incidence and survival rates remained generally stable for pilocytic astrocytomas, medulloblastomas, and germ cell tumors. Increasing incidence was observed for spinal ependymomas, mostly for myxopapillary ependymomas, and survival improved over time for grade II ependymomas (P
KW - ependymoma
KW - epidemiology
KW - intracranial germ cell tumor
KW - medulloblastoma
KW - pilocytic astrocytoma
KW - ependymoma
KW - epidemiology
KW - intracranial germ cell tumor
KW - medulloblastoma
KW - pilocytic astrocytoma
UR - https://www.scopus.com/pages/publications/85134979336
UR - https://www.mendeley.com/catalogue/abbde974-6954-328f-ab43-8c54556c7376/
U2 - 10.1093/noajnl/vdac062
DO - 10.1093/noajnl/vdac062
M3 - Article
C2 - 35664556
AN - SCOPUS:85134979336
SN - 2632-2498
VL - 4
SP - vdac062
JO - Neuro-Oncology Advances
JF - Neuro-Oncology Advances
IS - 1
M1 - vdac062
ER -