Recombination and joining: different means to the same ends.

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)

Abstract

DNA double-strand breaks are very genotoxic lesions that can result in chromosome aberrations. The current view is that DNA double-strand breaks are repaired most efficiently through homologous recombination in yeast and simple end-joining in mammalian cells. However, recent experiments reveal that both repair pathways are conserved from yeast to mammals, including humans. The challenge ahead is to put the different pieces of the jigsaw together into coherent mechanisms for both pathways and to determine their relative contributions to ionizing-radiation resistance and to the prevention of genetic instability and carcinogenesis.

Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalGenes and function
Volume1
Issue number3
DOIs
Publication statusPublished - Jun 1997
Externally publishedYes

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