Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Gitte Berkers, Peter van Mourik, Annelotte M. Vonk, Evelien Kruisselbrink, Johanna F. Dekkers, Karin M. de Winter-de Groot, Hubertus G.M. Arets, Rozemarijn E.P. Marck-van der Wilt, Jasper S. Dijkema, Maaike M. Vanderschuren, Roderick H.J. Houwen, Harry G.M. Heijerman, Eduard A. van de Graaf, Sjoerd G. Elias, Christof J. Majoor, Gerard H. Koppelman, Jolt Roukema, Marleen Bakker, Hettie M. Janssens, Renske van der MeerRobert G.J. Vries, Hans C. Clevers, Hugo R. de Jonge, Jeffrey M. Beekman, Cornelis K. van der Ent

Research output: Contribution to journalArticlepeer-review

191 Citations (Scopus)

Abstract

Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.

Original languageEnglish
Pages (from-to)1701-1708.e3
JournalCell Reports
Volume26
Issue number7
DOIs
Publication statusPublished - 12 Feb 2019
Externally publishedYes

Keywords

  • CFTR
  • cystic fibrosis
  • drug response
  • organoids
  • personalized treatment
  • predicting
  • stem cell cultures

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