Reduced versus intensive chemotherapy for childhood acute lymphoblastic leukemia: Impact on lymphocyte compartment composition

Cornelis M. Van Tilburg, Vincent H.J. van der Velden, Elisabeth A.M. Sanders, Tom F.W. Wolfs, Jacobus F. Gaiser, Valerie de Haas, Rob Pieters, Andries C. Bloem, Marc B. Bierings

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Chemotherapy for childhood acute lymphoblastic leukemia may cause severe immune damage. The lymphocyte compartment of 140 patients during and after a new strongly reduced (standard risk (SR), n=43) and intensive chemotherapy regimen (medium risk (MR), n=97) was studied between 2006 and 2009. Transitional and naive B cells and IgG+/A+, IgM+ and IgM only memory B cells were significantly reduced during chemotherapy; significantly more in MR group. One year after treatment CD27+IgG+/A+, IgM+ and IgM only memory B cells had still not fully recovered, but this was not confined to the MR group. The T cell compartment was less but also significantly affected during chemotherapy and recovered to normal levels. In the MR group, NK cells had not fully recovered to normal levels 1 year after treatment. Thus, intensive chemotherapy regimens cause severe, mainly B cell memory damage that persists even 1 year after treatment.

Original languageEnglish
Pages (from-to)484-491
Number of pages8
JournalLeukemia Research
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • B-lymphocyte subsets
  • Child
  • Immunologic memory
  • T-lymphocyte subsets
  • Toxicity

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