Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

Jan M. Leerink, Helena J.H. van der Pal, Leontien C.M. Kremer, Elizabeth A.M. Feijen, Paola G. Meregalli, Milanthy S. Pourier, Remy Merkx, Louise Bellersen, Elvira C. van Dalen, Jacqueline Loonen, Yigal M. Pinto, Livia Kapusta, Annelies M.C. Mavinkurve-Groothuis, Wouter E.M. Kok

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In childhood cancer survivors (CCS) at risk for heart failure, echocardiographic surveillance recommendations are currently based on anthracyclines and chest-directed radiotherapy dose. Whether the ejection fraction (EF) measured at an initial surveillance echocardiogram can refine these recommendations is unknown. Objectives: The purpose of this study was to assess the added predictive value of EF at >5 years after cancer diagnosis to anthracyclines and chest-directed radiotherapy dose in CCS, for the development of left ventricular dysfunction with an ejection fraction
Original languageEnglish
Pages (from-to)62-72
Number of pages11
JournalJACC: CardioOncology
Volume3
Issue number1
DOIs
Publication statusPublished - 1 Mar 2021

Keywords

  • cardio-oncology
  • childhood cancer survivors
  • echocardiography
  • risk prediction model
  • surveillance

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