Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

Jan M. Leerink; Helena J.H. van der Pal; Leontien C.M. Kremer; Elizabeth A.M. Feijen; Paola G. Meregalli; Milanthy S. Pourier; Remy Merkx; Louise Bellersen; Elvira C. van Dalen; Jacqueline Loonen; Yigal M. Pinto; Livia Kapusta; Annelies M.C. Mavinkurve-Groothuis; Wouter E.M. Kok

doi:10.1016/j.jaccao.2020.11.013

Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

Jan M. Leerink
, Helena J.H. van der Pal
, Leontien C.M. Kremer
, Elizabeth A.M. Feijen
, Paola G. Meregalli
, Milanthy S. Pourier
, Remy Merkx
, Louise Bellersen
, Elvira C. van Dalen
, Jacqueline Loonen
, Yigal M. Pinto
, Livia Kapusta
, Annelies M.C. Mavinkurve-Groothuis
, Wouter E.M. Kok

Group Kremer

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Background: In childhood cancer survivors (CCS) at risk for heart failure, echocardiographic surveillance recommendations are currently based on anthracyclines and chest-directed radiotherapy dose. Whether the ejection fraction (EF) measured at an initial surveillance echocardiogram can refine these recommendations is unknown. Objectives: The purpose of this study was to assess the added predictive value of EF at >5 years after cancer diagnosis to anthracyclines and chest-directed radiotherapy dose in CCS, for the development of left ventricular dysfunction with an ejection fraction

Original language	English
Pages (from-to)	62-72
Number of pages	11
Journal	JACC: CardioOncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.jaccao.2020.11.013
Publication status	Published - 1 Mar 2021

Keywords

cardio-oncology
childhood cancer survivors
echocardiography
risk prediction model
surveillance

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10.1016/j.jaccao.2020.11.013

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Leerink, J. M., van der Pal, H. J. H., Kremer, L. C. M., Feijen, E. A. M., Meregalli, P. G., Pourier, M. S., Merkx, R., Bellersen, L., van Dalen, E. C., Loonen, J., Pinto, Y. M., Kapusta, L., Mavinkurve-Groothuis, A. M. C., & Kok, W. E. M. (2021). Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer. JACC: CardioOncology, 3(1), 62-72. https://doi.org/10.1016/j.jaccao.2020.11.013

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title = "Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer",

abstract = "Background: In childhood cancer survivors (CCS) at risk for heart failure, echocardiographic surveillance recommendations are currently based on anthracyclines and chest-directed radiotherapy dose. Whether the ejection fraction (EF) measured at an initial surveillance echocardiogram can refine these recommendations is unknown. Objectives: The purpose of this study was to assess the added predictive value of EF at >5 years after cancer diagnosis to anthracyclines and chest-directed radiotherapy dose in CCS, for the development of left ventricular dysfunction with an ejection fraction ",

keywords = "cardio-oncology, childhood cancer survivors, echocardiography, risk prediction model, surveillance",

author = "Leerink, \{Jan M.\} and \{van der Pal\}, \{Helena J.H.\} and Kremer, \{Leontien C.M.\} and Feijen, \{Elizabeth A.M.\} and Meregalli, \{Paola G.\} and Pourier, \{Milanthy S.\} and Remy Merkx and Louise Bellersen and \{van Dalen\}, \{Elvira C.\} and Jacqueline Loonen and Pinto, \{Yigal M.\} and Livia Kapusta and Mavinkurve-Groothuis, \{Annelies M.C.\} and Kok, \{Wouter E.M.\}",

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year = "2021",

month = mar,

day = "1",

doi = "10.1016/j.jaccao.2020.11.013",

language = "English",

volume = "3",

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Leerink, JM , van der Pal, HJH , Kremer, LCM , Feijen, EAM, Meregalli, PG, Pourier, MS, Merkx, R, Bellersen, L, van Dalen, EC, Loonen, J, Pinto, YM, Kapusta, L, Mavinkurve-Groothuis, AMC & Kok, WEM 2021, 'Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer', JACC: CardioOncology, vol. 3, no. 1, pp. 62-72. https://doi.org/10.1016/j.jaccao.2020.11.013

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T1 - Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

AU - Leerink, Jan M.

AU - van der Pal, Helena J.H.

AU - Kremer, Leontien C.M.

AU - Feijen, Elizabeth A.M.

AU - Meregalli, Paola G.

AU - Pourier, Milanthy S.

AU - Merkx, Remy

AU - Bellersen, Louise

AU - van Dalen, Elvira C.

AU - Loonen, Jacqueline

AU - Pinto, Yigal M.

AU - Kapusta, Livia

AU - Mavinkurve-Groothuis, Annelies M.C.

AU - Kok, Wouter E.M.

PY - 2021/3/1

Y1 - 2021/3/1

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KW - cardio-oncology

KW - childhood cancer survivors

KW - echocardiography

KW - risk prediction model

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JF - JACC: CardioOncology

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Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

Abstract

Keywords

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