Relevance of microRNAs in normal and malignant development, including human testicular germ cell tumours

L H J Looijenga, A J M Gillis, H Stoop, R Hersmus, J W Oosterhuis

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


The dogma of genome functionality has recently been challenged by identification of non-protein-encoding RNAs, including mi(cro)RNAs. These relatively small sequences interact with mRNA and in the mammalian system, are involved in fine-tuning the process of translation. miRNAs have been found to be of crucial importance for normal development, including stem cell formation. Recent interesting fundamental observations will be discussed in this paper, as well as their impact on the genesis of human germ cell tumours (GCTs), in particular those of the adult testis, seminomas and non-seminomas (type II), and spermatocytic seminomas (type III). miRNA cluster 371-373 is specifically involved in inhibition of cellular senescence induced by oncogenic stress in the type II GCTs. This explains the unusual presence of wild type P53, characteristic of this type of solid cancer. Specific sets of differentiating miRNA were found to characterize the various differentiation lineages within the GCTs, which simulate normal embryonic development.

Original languageEnglish
Pages (from-to)304-14; discussion 314-5
Number of pages12
JournalInternational journal of andrology
Issue number4
Publication statusPublished - Aug 2007
Externally publishedYes


  • DNA, Neoplasm/genetics
  • Genome, Human
  • Humans
  • Male
  • MicroRNAs/genetics
  • Mutation
  • Neoplasms/genetics
  • Neoplasms, Germ Cell and Embryonal/genetics
  • RNA, Neoplasm/genetics
  • Testicular Neoplasms/genetics


Dive into the research topics of 'Relevance of microRNAs in normal and malignant development, including human testicular germ cell tumours'. Together they form a unique fingerprint.

Cite this